Blacksell, Stuart D; Dhawan, Sandhya; Kusumoto, Marina; Khanh Le, Kim; Summermatter, Katharina; O'Keefe, Joseph; Kozlovac, Joseph; Al Muhairi, Salama Suhail; Sendow, Indrawati; Scheel, Christina M; Ahumibe, Anthony; Masuku, Zibusiso M; Bennett, Allan M; Kojima, Kazunobu; Harper, David R; Hamilton, Keith (2023). The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Mpox/Monkeypox Virus. Applied Biosafety, 28(3), pp. 152-161. Mary Ann Liebert 10.1089/apb.2022.0045
|
Text
apb.2022.0045.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (241kB) | Preview |
INTRODUCTION
The virus formerly known as monkeypox virus, now called mpoxv, belongs to the Orthopoxvirus genus and can cause mpox disease through both animal-to-human and human-to-human transmission. The unexpected spread of mpoxv among humans has prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern (PHEIC).
METHODS
We conducted a literature search to identify the gaps in biosafety, focusing on five main areas: how the infection enters the body and spreads, how much of the virus is needed to cause infection, infections acquired in the lab, accidental release of the virus, and strategies for disinfecting and decontaminating the area.
DISCUSSION
The recent PHEIC has shown that there are gaps in our knowledge of biosafety when it comes to mpoxv. We need to better understand where this virus might be found, how much of it can spread from person-to-person, what are the effective control measures, and how to safely clean up contaminated areas. By gathering more biosafety evidence, we can make better decisions to protect people from this zoonotic agent, which has recently become more common in the human population.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology |
UniBE Contributor: |
Summermatter, Kathrin |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2470-1246 |
Publisher: |
Mary Ann Liebert |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Sep 2023 10:33 |
Last Modified: |
26 Sep 2023 10:42 |
Publisher DOI: |
10.1089/apb.2022.0045 |
PubMed ID: |
37736424 |
Uncontrolled Keywords: |
biosafety evidence biosafety knowledge gaps mpox mpox virus pathogen characteristics |
BORIS DOI: |
10.48350/186516 |
URI: |
https://boris.unibe.ch/id/eprint/186516 |
Actions (login required)
 |
Edit item |