Frehner, Lorenz; Haefliger, Simon; Cerciello, Ferdinando; Grob, Tobias; Schmid, Sabine (2023). Complete Response on Larotrectinib in NTRK2 Fusion-Positive Non-Small Cell Lung Cancer. Case reports in oncology, 16(1), pp. 871-877. Karger 10.1159/000533572
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In patients with non-small cell lung cancer (NSCLC) harboring a fusion of the neurotrophic receptor kinase (NTRK) gene 1 or 3, treatment with tropomyosin kinase (TRK) inhibitors have shown promising results, however so far no data on efficacy of these agents in patients with NSCLC and NTRK2 fusion are available. We present a case of a female patient with NTRK2-positive NSCLC with a complete ongoing response on therapy with larotrectinib, suggesting efficacy of first-generation TRK inhibitors also in NTRK2-positive NSCLC.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Frehner, Lorenz Hermann, Häfliger, Simon, Cerciello, Ferdinando, Grob, Tobias, Schmid, Sabine |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1662-6575 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 Oct 2023 14:04 |
Last Modified: |
31 Oct 2023 13:30 |
Publisher DOI: |
10.1159/000533572 |
PubMed ID: |
37900816 |
Uncontrolled Keywords: |
NTRK2 Non-small cell lung cancer Targeted therapy |
BORIS DOI: |
10.48350/188324 |
URI: |
https://boris.unibe.ch/id/eprint/188324 |
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