Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome.

Tessitore, Elena; Branca, Mattia; Heg, Dik; Nanchen, David; Auer, Reto; Räber, Lorenz; Klingenberg, Roland; Windecker, Stephan; Lüscher, Thomas F; Carballo, Sebastian; Matter, Christian M; Gmel, Gerhard; Mukamal, Kenneth J; Rodondi, Nicolas; Carballo, David; Mach, François; Gencer, Baris (2024). Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome. European journal of preventive cardiology, 31(7), pp. 845-855. Oxford University Press 10.1093/eurjpc/zwad364

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AIM

To evaluate the risk of alcohol consumption after acute coronary syndromes (ACS).

METHODS

A total of 6557 patients hospitalized for ACS at 4 Swiss centres were followed over 12 months. Weekly alcohol consumption was collected at baseline and 12 months. Binge drinking was defined as consumption of ≥6 units of alcohol on one occasion. Major adverse cardiovascular events (MACE) were defined as a composite of cardiac death, myocardial infarction, stroke or clinically indicated target vessel coronary revascularization. Cox regression analysis was performed to assess the risk of MACE in patients with heavy (>14 standard units/week), moderate (7-14 standard units per week), light consumption (<1 standard unit/week) or abstinence, and with binge drinking episodes, adjusted for baseline differences.

RESULTS

At baseline, 817 (13.4%) patients reported heavy weekly alcohol consumption. At one-year follow-up, 695/1667 (41.6%) patients reported having at least one or more episodes of binge drinking per month. The risk for MACE was not significantly higher in those with heavy weekly consumption compared to abstinence (8.6% vs. 10.2%, HR 0.97, 95%CI 0.69-1.36) or light consumption (8.6% vs. 8.5 %, HR 1.41, 95%CI 0.97-2.06). Compared to patients with no-binge drinking, the risk of MACE was dose-dependently higher in those with binge drinking with less than one episode per month (9.2% vs 7.8%, HR 1.61, 95%CI 1.23-2.11), or one or more episodes per month (13.6% vs 7.8%, HR 2.17, 95%CI 1.66-2.83).

CONCLUSION

Binge drinking during the year following an ACS, even less than once per month, is associated with worse clinical outcomes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Branca, Mattia, Heg, Dierik Hans, Auer, Reto, Räber, Lorenz, Windecker, Stephan, Rodondi, Nicolas, Gencer, Baris Faruk

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2047-4881

Publisher:

Oxford University Press

Funders:

[4] Swiss National Science Foundation ; [116] Swiss Heart Foundation = Schweizerische Herzstiftung

Language:

English

Submitter:

Pubmed Import

Date Deposited:

24 Nov 2023 13:24

Last Modified:

04 Jun 2024 19:31

Publisher DOI:

10.1093/eurjpc/zwad364

PubMed ID:

37995305

Uncontrolled Keywords:

acute coronary syndromes alcohol consumption binge drinking cardiovascular prevention lifestyle secondary cardiovascular prevention

BORIS DOI:

10.48350/189336

URI:

https://boris.unibe.ch/id/eprint/189336

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