Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome.

Tessitore, Elena; Branca, Mattia; Heg, Dik; Nanchen, David; Auer, Reto; Räber, Lorenz; Klingenberg, Roland; Windecker, Stephan; Lüscher, Thomas F; Carballo, Sebastian; Matter, Christian M; Gmel, Gerhard; Mukamal, Kenneth J; Rodondi, Nicolas; Carballo, David; Mach, François; Gencer, Baris (2023). Drinking patterns of alcohol and risk of major adverse cardiovascular events after an acute coronary syndrome. (In Press). European journal of preventive cardiology Oxford University Press 10.1093/eurjpc/zwad364

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AIM

To evaluate the risk of alcohol consumption after acute coronary syndromes (ACS).

METHODS

A total of 6557 patients hospitalized for ACS at 4 Swiss centres were followed over 12 months. Weekly alcohol consumption was collected at baseline and 12 months. Binge drinking was defined as consumption of ≥6 units of alcohol on one occasion. Major adverse cardiovascular events (MACE) were defined as a composite of cardiac death, myocardial infarction, stroke or clinically indicated target vessel coronary revascularization. Cox regression analysis was performed to assess the risk of MACE in patients with heavy (>14 standard units/week), moderate (7-14 standard units per week), light consumption (<1 standard unit/week) or abstinence, and with binge drinking episodes, adjusted for baseline differences.

RESULTS

At baseline, 817 (13.4%) patients reported heavy weekly alcohol consumption. At one-year follow-up, 695/1667 (41.6%) patients reported having at least one or more episodes of binge drinking per month. The risk for MACE was not significantly higher in those with heavy weekly consumption compared to abstinence (8.6% vs. 10.2%, HR 0.97, 95%CI 0.69-1.36) or light consumption (8.6% vs. 8.5 %, HR 1.41, 95%CI 0.97-2.06). Compared to patients with no-binge drinking, the risk of MACE was dose-dependently higher in those with binge drinking with less than one episode per month (9.2% vs 7.8%, HR 1.61, 95%CI 1.23-2.11), or one or more episodes per month (13.6% vs 7.8%, HR 2.17, 95%CI 1.66-2.83).

CONCLUSION

Binge drinking during the year following an ACS, even less than once per month, is associated with worse clinical outcomes.

Interest & Impact

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5 Citations in Web of Science ®
6 Citations in Scopus

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