Manna, Sam; Werren, Joel P; Ortika, Belinda D; Bellich, Barbara; Pell, Casey L; Nikolaou, Elissavet; Gjuroski, Ilche; Lo, Stephanie; Hinds, Jason; Tundev, Odgerel; Dunne, Eileen M; Gessner, Bradford D; Bentley, Stephen D; Russell, Fiona M; Mulholland, E Kim; Mungun, Tuya; von Mollendorf, Claire; Licciardi, Paul V; Cescutti, Paola; Ravenscroft, Neil; ... (2024). Streptococcus pneumoniae serotype 33G: genetic, serological, and structural analysis of a new capsule type. Microbiology spectrum, 12(1), e0357923. American Society for Microbiology 10.1128/spectrum.03579-23
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manna-et-al-2023-streptococcus-pneumoniae-serotype-33g-genetic-serological-and-structural-analysis-of-a-new-capsule-type.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Streptococcus pneumoniae (the pneumococcus) is a bacterial pathogen with the greatest burden of disease in Asia and Africa. The pneumococcal capsular polysaccharide has biological relevance as a major virulence factor as well as public health importance as it is the target for currently licensed vaccines. These vaccines have limited valency, covering up to 23 of the >100 known capsular types (serotypes) with higher valency vaccines in development. Here, we have characterized a new pneumococcal serotype, which we have named 33G. We detected serotype 33G in nasopharyngeal swabs (n = 20) from children and adults hospitalized with pneumonia, as well as healthy children in Mongolia. We show that the genetic, serological, and biochemical properties of 33G differ from existing serotypes, satisfying the criteria to be designated as a new serotype. Future studies should focus on the geographical distribution of 33G and any changes in prevalence following vaccine introduction.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Werren, Joel Pascal, Gjuroski, Ilche, Hilty, Markus |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 600 Technology > 610 Medicine & health |
ISSN: |
2165-0497 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Dec 2023 09:55 |
Last Modified: |
13 Jan 2024 00:16 |
Publisher DOI: |
10.1128/spectrum.03579-23 |
PubMed ID: |
38059623 |
Uncontrolled Keywords: |
Streptococcus pneumoniae capsule recombination serotypes vaccines |
BORIS DOI: |
10.48350/190017 |
URI: |
https://boris.unibe.ch/id/eprint/190017 |
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