How Do I Manage Refractory Invasive Pulmonary Aspergillosis.

Vergidis, Paschalis; Sendi, Parham; Alkhateeb, Hassan; Nguyen, M Hong (2024). How Do I Manage Refractory Invasive Pulmonary Aspergillosis. Clinical microbiology and infection, 30(6), pp. 755-761. Elsevier 10.1016/j.cmi.2024.01.015

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BACKGROUND

Invasive aspergillosis is associated with significant morbidity and mortality in patients with hematologic malignancies and hematopoietic cell transplant recipients. The prognosis is worse among patients who have failed primary antifungal treatment.

OBJECTIVES

We aim to provide guidance on the diagnosis and management of refractory invasive pulmonary aspergillosis.

SOURCES

Using PubMed we performed a review of original articles, meta-analyses, and systematic reviews.

CONTENT

We discuss the diagnostic criteria for invasive pulmonary aspergillosis and the evidence on treatment of primary infection. We outline our diagnostic approach to refractory disease. We propose a treatment algorithm for refractory disease and discuss the role of experimental antifungal agents.

IMPLICATIONS

For patients with worsening disease while on antifungal therapy, a thorough diagnostic evaluation is required to confirm the diagnosis of aspergillosis and exclude another concomitant infection. Treatment should be individualized. Current options include switching to another triazole, transitioning to a lipid formulation of amphotericin B, or using combination antifungal therapy.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Sendi, Parham

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1469-0691

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

30 Jan 2024 09:47

Last Modified:

29 May 2024 00:13

Publisher DOI:

10.1016/j.cmi.2024.01.015

PubMed ID:

38286175

Uncontrolled Keywords:

Aspergillosis Hematopoietic stem cell transplant Leukemia invasive fungal infection invasive mold infection refractory infection

BORIS DOI:

10.48350/192237

URI:

https://boris.unibe.ch/id/eprint/192237

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