Electronic Nicotine-Delivery Systems for Smoking Cessation.

Auer, Reto; Schoeni, Anna; Humair, Jean-Paul; Jacot-Sadowski, Isabelle; Berlin, Ivan; Stuber, Mirah J.; Haller, Moa Lina; Casagrande Tango, Rodrigo; Frei, Anna; Strassmann, Alexandra; Bruggmann, Philip; Baty, Florent; Brutsche, Martin; Tal, Kali; Baggio, Stéphanie; Jakob, Julian; Sambiagio, Nicolas; Hopf, Nancy B.; Feller, Martin; Rodondi, Nicolas; ... (2024). Electronic Nicotine-Delivery Systems for Smoking Cessation. New England journal of medicine NEJM, 390(7), pp. 601-610. Massachusetts Medical Society MMS 10.1056/NEJMoa2308815

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Background: Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these systems is needed.

Methods: In this open-label, controlled trial, we randomly assigned adults who were smoking at least five tobacco cigarettes per day and who wanted to set a quit date to an intervention group, which received free e-cigarettes and e-liquids, standard-of-care smoking-cessation counseling, and optional (not free) nicotine-replacement therapy, or to a control group, which received standard counseling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. The primary outcome was biochemically validated, continuous abstinence from smoking at 6 months. Secondary outcomes included participant-reported abstinence from tobacco and from any nicotine (including smoking, e-cigarettes, and nicotine-replacement therapy) at 6 months, respiratory symptoms, and serious adverse events.

Results: A total of 1246 participants underwent randomization; 622 participants were assigned to the intervention group, and 624 to the control group. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The percentage of participants who abstained from smoking in the 7 days before the 6-month visit was 59.6% in the intervention group and 38.5% in the control group, but the percentage who abstained from any nicotine use was 20.1% in the intervention group and 33.7% in the control group. Serious adverse events occurred in 25 participants (4.0%) in the intervention group and in 31 (5.0%) in the control group; adverse events occurred in 272 participants (43.7%) and 229 participants (36.7%), respectively.

Conclusions: The addition of e-cigarettes to standard smoking-cessation counseling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counseling alone. (Funded by the Swiss National Science Foundation and others; ESTxENDS ClinicalTrials.gov number, NCT03589989.).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Auer, Reto, Schöni, Anna, Stuber, Mirah Julia, Haller, Moa Lina, Tal, Kali, Baggio, Stéphanie, Jakob, Julian, Feller, Martin, Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0028-4793

Publisher:

Massachusetts Medical Society MMS

Funders:

[4] Swiss National Science Foundation ; [236] Swiss Tobacco Prevention Fund = Tabakpräventionsfonds ; [189] Swiss Cancer Research = Krebsforschung Schweiz ; [255] Lunge Zürich

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

14 Feb 2024 16:48

Last Modified:

23 Feb 2024 12:35

Publisher DOI:

10.1056/NEJMoa2308815

PubMed ID:

38354139

BORIS DOI:

10.48350/192903

URI:

https://boris.unibe.ch/id/eprint/192903

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