Zeeb, Marius; Frischknecht, Paul; Huber, Michael; Schenkel, Corinne D; Neumann, Kathrin; Leeman, Christine; Notter, Julia; Rauch, Andri; Stöckle, Marcel; Cavassini, Matthias; Bernasconi, Enos; Braun, Dominique L; Günthard, Huldrych F; Metzner, Karin J; Kouyos, Roger D (2024). Genetic diversity from proviral DNA as a proxy for time since HIV-1 infection. (In Press). The journal of infectious diseases Oxford University Press 10.1093/infdis/jiae149
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HIV-1 RNA genetic diversity predicts time since infection which is important for clinical care and research. It's unclear, however, whether proviral DNA genetic diversity sampled under suppressive antiretroviral therapy can be used for this purpose. We tested whether proviral genetic diversity from NGS sequences predicts time since infection and recency in 221 people with HIV-1 with known infection time. Proviral diversity was significantly associated with time since infection (p<5*10-07, R2 up to 25%) and predictive of treatment initiation during recent infection (AUC-ROC up to 0.85). This shows the utility of proviral genetic diversity as a proxy for time since infection.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1537-6613 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 Apr 2024 11:26 |
Last Modified: |
11 Apr 2024 02:20 |
Publisher DOI: |
10.1093/infdis/jiae149 |
PubMed ID: |
38507572 |
Uncontrolled Keywords: |
HIV-1 infection recency next-generation sequencing proviral diversity time since infection |
BORIS DOI: |
10.48350/194587 |
URI: |
https://boris.unibe.ch/id/eprint/194587 |
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