Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation.

Stillinovic, Martina; Sarangdhar, Mayuresh Anant; Andina, Nicola; Tardivel, Aubry; Greub, Frédéric; Bombaci, Giuseppe; Ansermet, Camille; Zatti, Marco; Saha, Dipanjali; Xiong, Jieyu; Sagae, Takeru; Yokogawa, Mariko; Osawa, Masanori; Heller, Manfred; Keogh, Adrian; Keller, Irene; Angelillo-Scherrer, Anne; Allam, Ramanjaneyulu (2024). Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation. Science Advances, 10(22) American Association for the Advancement of Science 10.1126/sciadv.adl0320

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Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type-specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type-specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non-hematopoietic-origin cells. RNH1-mediated cell type-specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type-specific global translation regulators and highlights the complex translation regulation in vertebrates.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
Graduate Schools > Graduate School for Cellular and Biomedical Sciences (GCB)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hämatologie / Onkologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hämatologie / Onkologie (Pädiatrie)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Sarangdhar, Mayuresh Anant, Andina, Nicola, Tardivel, Aubry Bernard Maurice, Greub, Frédéric, Bombaci, Giuseppe, Ansermet, Camille Eva, Zatti, Marco, Saha, Dipanjali, Xiong, Jieyu, Heller, Manfred, Keogh, Adrian, Keller, Irene (B), Angelillo, Anne, Allam, Ramanjaneyulu

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

2375-2548

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Pubmed Import

Date Deposited:

03 Jun 2024 11:16

Last Modified:

04 Jun 2024 03:13

Publisher DOI:

10.1126/sciadv.adl0320

PubMed ID:

38820160

BORIS DOI:

10.48350/197427

URI:

https://boris.unibe.ch/id/eprint/197427

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