Zbinden, Andrea; Seth-Smith, Helena M B; Beltrami, Vanessa; Mancini, Stefano; Droz, Sara; Bürgi, Urs; Melillo, David; Schuurmans, Mace M; Schwizer, Bernhard; Schmid, Iris; Casaulta, Carmen; Barben, Jürg; Mueller, Nicolas J; Imkamp, Frank (2024). Burkholderia cenocepacia ST-250 in cystic fibrosis patients in Switzerland: Genomic investigation of transmission routes. (In Press). Diagnostic microbiology and infectious disease, 110(2), p. 116429. Elsevier 10.1016/j.diagmicrobio.2024.116429
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This report describes the characterization of Burkholderia cenocepacia isolates belonging to sequence type (ST)-250, detected in eight patients with cystic fibrosis (CF) in Switzerland. We retrospectively analyzed 18 isolates of B. cenocepacia ST-250 isolated between 2003 and 2015 by whole-genome sequencing and evaluated clinical and epidemiological data. Single nucleotide polymorphism analysis of the B.°cenocepacia ST-250 lineage showed that the isolates from all patients cluster tightly, suggesting that this cluster has a recent common ancestor. Epidemiological investigations showed that six out of eight patients acquired B.°cenocepacia ST-250 in the years 2001-2006, where participation in CF summer camps was common. Two patients were siblings. Genomic relatedness of the B. cenocepacia ST-250 isolates supported transmission by close contact, however, a common source or nosocomial routes cannot be excluded. With respect to the fatal outcome in six patients, our study shows the importance of infection control measurements in CF patients with B.°cenocepacia.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Clinical Microbiology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > General Bacteriology |
UniBE Contributor: |
Droz, Sara Christine, Casaulta, Carmen |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0732-8893 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
09 Aug 2024 13:33 |
Last Modified: |
10 Aug 2024 12:57 |
Publisher DOI: |
10.1016/j.diagmicrobio.2024.116429 |
PubMed ID: |
39116652 |
Uncontrolled Keywords: |
Burkholderia cenocepacia Cystic fibrosis Genomic relatedness Transmission |
BORIS DOI: |
10.48350/199603 |
URI: |
https://boris.unibe.ch/id/eprint/199603 |
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