Ezrin/radixin/moesin: Versatile controllers of signaling molecules and of the cortical cytoskeleton

Niggli, Verena; Rossy, Jérémie (2008). Ezrin/radixin/moesin: Versatile controllers of signaling molecules and of the cortical cytoskeleton. International journal of biochemistry & cell biology, 40(3), pp. 344-9. Amsterdam: Elsevier 10.1016/j.biocel.2007.02.012

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Ezrin, radixin and moesin (ERM) proteins are widely distributed proteins located in the cellular cortex, in microvilli and adherens junctions. They feature an N-terminal membrane binding domain linked by an alpha-helical domain to the C-terminal actin-binding domain. In the dormant state, binding sites in the N-terminal domain are masked by interactions with the C-terminal region. The alpha-helical domain also contributes to masking of binding sites. A specific sequence of signaling events results in dissociation of these intramolecular interactions resulting in ERM activation. ERM molecules have been implicated in mediating actin-membrane linkage and in regulating signaling molecules. They are involved in cell membrane organization, cell migration, phagocytosis and apoptosis, and may also play cell-specific roles in tumor progression. Their precise involvement in these processes has yet to be elucidated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Niggli, Verena and Rossy, Jérémie

ISSN:

1357-2725

ISBN:

17419089

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:53

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/j.biocel.2007.02.012

PubMed ID:

17419089

Web of Science ID:

000254119100004

URI:

https://boris.unibe.ch/id/eprint/22673 (FactScience: 35914)

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