Niggli, Verena; Rossy, Jérémie (2008). Ezrin/radixin/moesin: Versatile controllers of signaling molecules and of the cortical cytoskeleton. International journal of biochemistry & cell biology, 40(3), pp. 344-9. Amsterdam: Elsevier 10.1016/j.biocel.2007.02.012
Full text not available from this repository.Ezrin, radixin and moesin (ERM) proteins are widely distributed proteins located in the cellular cortex, in microvilli and adherens junctions. They feature an N-terminal membrane binding domain linked by an alpha-helical domain to the C-terminal actin-binding domain. In the dormant state, binding sites in the N-terminal domain are masked by interactions with the C-terminal region. The alpha-helical domain also contributes to masking of binding sites. A specific sequence of signaling events results in dissociation of these intramolecular interactions resulting in ERM activation. ERM molecules have been implicated in mediating actin-membrane linkage and in regulating signaling molecules. They are involved in cell membrane organization, cell migration, phagocytosis and apoptosis, and may also play cell-specific roles in tumor progression. Their precise involvement in these processes has yet to be elucidated.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Niggli, Verena, Rossy, Jérémie |
ISSN: |
1357-2725 |
ISBN: |
17419089 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:53 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1016/j.biocel.2007.02.012 |
PubMed ID: |
17419089 |
Web of Science ID: |
000254119100004 |
URI: |
https://boris.unibe.ch/id/eprint/22673 (FactScience: 35914) |
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