NPY receptors in human cancer: a review of current knowledge

Körner, Meike; Reubi, Jean Claude (2007). NPY receptors in human cancer: a review of current knowledge. Peptides, 28(2), pp. 419-25. New York, N.Y.: Elsevier 10.1016/j.peptides.2006.08.037

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Many peptide hormone receptors are over-expressed in human cancer, permitting an in vivo targeting of tumors for diagnostic and therapeutic purposes. NPY receptors are novel and promising candidates in this field. Using in vitro receptor autoradiography, Y1 and Y2 receptors have been found to be expressed in breast carcinomas, adrenal gland and related tumors, renal cell carcinomas, and ovarian cancers in both tumor cells and tumor-associated blood vessels. Pathophysiologically, tumoral NPY receptors may be activated by endogenous NPY released from intratumoral nerve fibers or tumor cells themselves, and mediate NPY effects on tumor cell proliferation and tumoral blood supply. Clinically, tumoral NPY receptors may be targeted with NPY analogs coupled with adequate radionuclides or cytotoxic agents for a scintigraphic tumor imaging and/or tumor therapy.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Körner Jachertz, Meike and Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0196-9781

ISBN:

17223228

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

17 Oct 2019 09:58

Publisher DOI:

10.1016/j.peptides.2006.08.037

PubMed ID:

17223228

Web of Science ID:

000244539800032

URI:

https://boris.unibe.ch/id/eprint/22751 (FactScience: 36420)

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