Apoptosis regulation by autophagy gene 5

Yousefi, Shida; Simon, Hans-Uwe (2007). Apoptosis regulation by autophagy gene 5. Critical reviews in oncology, hematology, 63(3), pp. 241-4. Boca Raton, Fla.: Elsevier 10.1016/j.critirevonc.2007.06.005

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Autophagy is a cellular process, in which cellular proteins and cytoplasmic organelles are degraded. It reflects the response of a cell to stress or starvation with the primary goal of cell survival. On the other hand, if the autophagic activity is too high, cell death happens, suggesting that this process requires a tight control. Autophagic cell death has often been observed under conditions, in which apoptosis is blocked. Recent studies suggest that autophagy may promote apoptosis and that Bcl-2 cannot block only apoptosis, but also autophagy and autophagic cell death. Here, we discuss recent findings regarding the interrelations between autophagy and apoptosis. In particular, we would like to draw the attention of the readers to Atg5, which exhibits, like Bcl-2, a dual function by modulating both autophagy and apoptosis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Yousefi, Shida and Simon, Hans-Uwe

ISSN:

1040-8428

ISBN:

17644402

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/j.critirevonc.2007.06.005

PubMed ID:

17644402

Web of Science ID:

000249292100005

URI:

https://boris.unibe.ch/id/eprint/22993 (FactScience: 38488)

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