Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma

Sibold, Sonja; Roh, Vincent; Keogh, Adrian; Studer, Peter; Tiffon, Céline; Angst, Eliane; Vorburger, Stephan A; Weimann, Rosemarie; Candinas, Daniel; Stroka, Deborah (2007). Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS letters, 581(5), pp. 989-94. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.080

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NDRG1 is a hypoxia-inducible protein, whose modulated expression is associated with the progression of human cancers. Here, we reveal that NDRG1 is markedly upregulated in the cytoplasm and on the membrane in human hepatocellular carcinoma (HCC). We demonstrate further that hypoxic stress increases the cytoplasmic expression of NDRG1 in vitro, but does not result in its localization on the plasma membrane. However, grown within an HCC-xenograft in vivo, cells express NDRG1 in the cytoplasm and on the plasma membrane. In conclusion, hypoxia is a potent inducer of NDRG1 in HCCs, albeit requiring additional stimuli within the tumour microenvironment for its recruitment to the membrane.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Roh, Vincent; Studer, Peter; Vorburger, Stephan; Weimann, Rosemarie; Candinas, Daniel and Keogh-Stroka, Deborah M.

ISSN:

0014-5793

ISBN:

17316623

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1016/j.febslet.2007.01.080

PubMed ID:

17316623

Web of Science ID:

000244941100033

URI:

https://boris.unibe.ch/id/eprint/23110 (FactScience: 39267)

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