Gerber, CM; Cottagnoud, M; Neftel, K; Täuber, MG; Cottagnoud, P (2000). Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro. Journal of antimicrobial chemotherapy, 45(1), pp. 63-8. Oxford: Oxford University Press 10.1093/jac/45.1.63
Full text not available from this repository. (Request a copy)Cefepime, a broad-spectrum, fourth-generation cephalosporin, showed excellent CSF penetration with levels ranging between 10 and 16 mg/L after two intravenous injections (100 mg/kg). The bactericidal activity of cefepime (-0.60 +/- 0.28 Deltalog(10) cfu/mL/h) was superior to that of ceftriaxone (-0.34 +/- 0.23 Deltalog(10) cfu/mL/h, P < 0.05) and vancomycin (-0.39 +/- 0.19 Deltalog(10) cfu/mL/h, P < 0.05) in the treatment of rabbits with meningitis caused by an isolate highly resistant to penicillin (MIC of penicillin G: 4 mg/L). The addition of vancomycin to both cephalosporins did not significantly increase the killing rate compared with monotherapies (P > 0.05). Similar results were obtained in time-killing experiments in vitro.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0305-7453 |
ISBN: |
10629014 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
21 Feb 2023 15:43 |
Publisher DOI: |
10.1093/jac/45.1.63 |
PubMed ID: |
10629014 |
Web of Science ID: |
000085101400010 |
URI: |
https://boris.unibe.ch/id/eprint/25755 (FactScience: 60879) |
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