Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro

Gerber, CM; Cottagnoud, M; Neftel, K; Täuber, MG; Cottagnoud, P (2000). Evaluation of cefepime alone and in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro. Journal of antimicrobial chemotherapy, 45(1), pp. 63-8. Oxford: Oxford University Press 10.1093/jac/45.1.63

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Cefepime, a broad-spectrum, fourth-generation cephalosporin, showed excellent CSF penetration with levels ranging between 10 and 16 mg/L after two intravenous injections (100 mg/kg). The bactericidal activity of cefepime (-0.60 +/- 0.28 Deltalog(10) cfu/mL/h) was superior to that of ceftriaxone (-0.34 +/- 0.23 Deltalog(10) cfu/mL/h, P < 0.05) and vancomycin (-0.39 +/- 0.19 Deltalog(10) cfu/mL/h, P < 0.05) in the treatment of rabbits with meningitis caused by an isolate highly resistant to penicillin (MIC of penicillin G: 4 mg/L). The addition of vancomycin to both cephalosporins did not significantly increase the killing rate compared with monotherapies (P > 0.05). Similar results were obtained in time-killing experiments in vitro.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
UniBE Contributor:	Täuber, Martin G.
ISSN:	0305-7453
ISBN:	10629014
Publisher:	Oxford University Press
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:00
Last Modified:	21 Feb 2023 15:43
Publisher DOI:	10.1093/jac/45.1.63
PubMed ID:	10629014
Web of Science ID:	000085101400010
URI:	https://boris.unibe.ch/id/eprint/25755 (FactScience: 60879)