Rifampin for therapy of experimental pneumococcal meningitis in rabbits

Nau, R; Kaye, K; Sachdeva, M; Sande, ER; Täuber, MG (1994). Rifampin for therapy of experimental pneumococcal meningitis in rabbits. Antimicrobial agents and chemotherapy, 38(5), pp. 1186-9. Washington, D.C.: American Society for Microbiology 10.1128/AAC.38.5.1186

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Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0066-4804

ISBN:

8067762

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1128/AAC.38.5.1186

PubMed ID:

8067762

Web of Science ID:

A1994NJ57500051

URI:

https://boris.unibe.ch/id/eprint/25786 (FactScience: 60941)

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