Nau, R; Kaye, K; Sachdeva, M; Sande, ER; Täuber, MG (1994). Rifampin for therapy of experimental pneumococcal meningitis in rabbits. Antimicrobial agents and chemotherapy, 38(5), pp. 1186-9. Washington, D.C.: American Society for Microbiology 10.1128/AAC.38.5.1186
Full text not available from this repository.Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0066-4804 |
ISBN: |
8067762 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1128/AAC.38.5.1186 |
PubMed ID: |
8067762 |
Web of Science ID: |
A1994NJ57500051 |
URI: |
https://boris.unibe.ch/id/eprint/25786 (FactScience: 60941) |
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