Meningitis in neonates: bench to bedside

Grandgirard, Denis; Leib, Stephen L. (2010). Meningitis in neonates: bench to bedside. Clinics in perinatology, 37(3), pp. 655-676. New York, N.Y.: Elsevier 10.1016/j.clp.2010.05.004

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The clinical outcome of central nervous system infection is determined by the characteristics of the pathogen and the brain's response to the invading bacteria. How infection leads to brain injury remains unresolved. An impediment to progress is the complexity of pathophysiologic processes. Some of the mechanisms involved have been identified in experimental models, providing insights into the molecular basis of brain injury and regeneration, and hinting at targets for therapy. Adjuvant therapies have been proposed. Interventions that protect the brain are evaluated for their potential to preserve neuro-integrative functions in long-term survivors of bacterial meningitis. This article summarizes current studies evaluating pharmacologic interventions in experimental models of bacterial meningitis and discusses how the knowledge gathered could translate into more effective therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Grandgirard, Denis and Leib, Stephen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0095-5108

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

24 Jul 2015 10:25

Publisher DOI:

10.1016/j.clp.2010.05.004

PubMed ID:

20813277

Web of Science ID:

000282534900010

BORIS DOI:

10.7892/boris.2683

URI:

https://boris.unibe.ch/id/eprint/2683 (FactScience: 205548)

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