Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas

Karamitopoulou, Eva; Tornillo, Luigi; Zlobec, Inti; Cioccari, Lukas; Carafa, Vincenza; Borner, Markus; Schaffner, Thomas; Brunner, Thomas; Diamantis, Ioannis; Zimmermann, Arthur; Terracciano, Luigi (2008). Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. American journal of clinical pathology, 130(5), pp. 780-6. Chicago, Ill.: American Society for Clinical Pathology 10.1309/AJCP35FDCAVANWMM

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Cholangiocarcinoma is the second most common malignant tumor of the liver. We analyzed, immunohistochemically, the significance of cell cycle- and apoptosis-related markers in 128 cholangiocarcinomas (42 intrahepatic, 70 extrahepatic, and 16 gallbladder carcinomas) combined in a tissue microarray. Follow-up was available for 57 patients (44.5%). In comparison with normal tissue (29 specimens), cholangiocarcinomas expressed significantly more frequently p53, bcl-2, bax, and COX-2 (P.05 <). Intrahepatic tumors were significantly more frequently bcl-2+ and p16+, whereas extrahepatic tumors were more often p53+ (P < .05). Loss of p16 expression was associated with reduced survival of patients. Our data show that p53, bcl-2, bax, and COX-2 have an important role in the pathogenesis of cholangiocarcinomas. The differential expression of p16, bcl-2, and p53 between intrahepatic and extrahepatic tumors demonstrates that there are location-related differences in the phenotype and the genetic profiles of these tumors. Moreover, p16 was identified as an important prognostic marker in cholangiocarcinomas.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Borner, Markus; Schaffner, Thomas; Brunner, Thomas and Zimmermann, Arthur

ISSN:

0002-9173

ISBN:

18854271

Publisher:

American Society for Clinical Pathology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1309/AJCP35FDCAVANWMM

PubMed ID:

18854271

Web of Science ID:

000260188600014

URI:

https://boris.unibe.ch/id/eprint/26900 (FactScience: 96357)

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