Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

Rauch, Andri; Kutalik, Zoltán; Descombes, Patrick; Cai, Tao; Di Iulio, Julia; Mueller, Tobias; Bochud, Murielle; Battegay, Manuel; Bernasconi, Enos; Borovicka, Jan; Colombo, Sara; Cerny, Andreas; Dufour, Jean-François; Furrer, Hansjakob; Günthard, Huldrych F; Heim, Markus; Hirschel, Bernard; Malinverni, Raffaele; Moradpour, Darius; Müllhaupt, Beat; ... (2010). Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology, 138(4), 1338-45, 1345.e1-7. Philadelphia, Pa.: Elsevier 10.1053/j.gastro.2009.12.056

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Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Rauch, Andri; Dufour, Jean-François and Furrer, Hansjakob

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

17 Mar 2015 19:15

Publisher DOI:

10.1053/j.gastro.2009.12.056

PubMed ID:

20060832

Web of Science ID:

000276091800023

URI:

https://boris.unibe.ch/id/eprint/2708 (FactScience: 205575)

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