Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus

Guglielmi, S; Merz, T M; Gugger, M; Suter, C; Nicod, L P (2008). Acute respiratory distress syndrome secondary to antisynthetase syndrome is reversible with tacrolimus. European respiratory journal, 31(1), pp. 213-7. Sheffield, UK: European Respiratory Society 10.1183/09031936.00014707

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Polymyositis and interstitial lung diseases, predominantly nonspecific interstitial pneumonia (NSIP), are known to be frequent in antisynthetase syndrome, where anti-aminoacyl-tRNA synthetase antibodies are often identified. An unusual case of acute respiratory distress syndrome, secondary to such proven NSIP of cellular type with predominant CD8 lymphocytes, is described herein. The patient described in the present case study initially had a poor recovery with high dose of steroids, but this was followed by a good improvement after the prescription of tacrolimus and a low dose of prednisone. A precise diagnosis in similar circumstances may be life-saving, allowing the successful application of new immunosuppressants.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Merz, Tobias, Gugger, Mathias, Nicod, Laurent






European Respiratory Society




Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

02 Mar 2023 23:22

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URI: (FactScience: 106805)

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