Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance

Yerly, Daniel; Heckerman, David; Allen, Todd M; Chisholm, John V; Faircloth, Kellie; Linde, Caitlyn H; Frahm, Nicole; Timm, Joerg; Pichler, Werner J; Cerny, Andreas; Brander, Christian (2008). Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance. Journal of virology, 82(6), pp. 3147-53. Baltimore: American Society for Microbiology 10.1128/JVI.02252-07

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Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Yerly, Daniel and Pichler, Werner Joseph

ISSN:

0022-538X

ISBN:

18184704

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1128/JVI.02252-07

PubMed ID:

18184704

Web of Science ID:

000253691000054

URI:

https://boris.unibe.ch/id/eprint/27646 (FactScience: 109789)

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