Yerly, Daniel; Heckerman, David; Allen, Todd M; Chisholm, John V; Faircloth, Kellie; Linde, Caitlyn H; Frahm, Nicole; Timm, Joerg; Pichler, Werner J; Cerny, Andreas; Brander, Christian (2008). Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance. Journal of virology, 82(6), pp. 3147-53. Baltimore: American Society for Microbiology 10.1128/JVI.02252-07
Full text not available from this repository. (Request a copy)Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology |
UniBE Contributor: |
Yerly, Daniel, Pichler, Werner Joseph |
ISSN: |
0022-538X |
ISBN: |
18184704 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:04 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1128/JVI.02252-07 |
PubMed ID: |
18184704 |
Web of Science ID: |
000253691000054 |
URI: |
https://boris.unibe.ch/id/eprint/27646 (FactScience: 109789) |
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