Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance

Yerly, Daniel; Heckerman, David; Allen, Todd M; Chisholm, John V; Faircloth, Kellie; Linde, Caitlyn H; Frahm, Nicole; Timm, Joerg; Pichler, Werner J; Cerny, Andreas; Brander, Christian (2008). Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance. Journal of virology, 82(6), pp. 3147-53. Baltimore: American Society for Microbiology 10.1128/JVI.02252-07

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Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
UniBE Contributor:	Yerly, Daniel, Pichler, Werner Joseph
ISSN:	0022-538X
ISBN:	18184704
Publisher:	American Society for Microbiology
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:04
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1128/JVI.02252-07
PubMed ID:	18184704
Web of Science ID:	000253691000054
URI:	https://boris.unibe.ch/id/eprint/27646 (FactScience: 109789)