Regulation of mitochondrial function by hypoxia and inflammation in sepsis: A putative role for hypoxia inducible factor

Regueira, Tomas Emilio; Jakob, Stephan; Djafarzadeh, Siamak (2008). Regulation of mitochondrial function by hypoxia and inflammation in sepsis: A putative role for hypoxia inducible factor. In: Vincent, Jean-Louis (ed.) Yearbook of Intensive Care and Emergency Medicine 2008 (pp. 385-394). Heidelberg: Springer 10.1007/978-3-540-77290-3_36

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Sepsis-related organ failure is the leading cause of mortality in European intensive care units (ICU). Although the inflammatory cascade of mediators in response to infection is well known, the relationships between regional inflammation, microvascular heterogeneity, hypoxia and hypoxia-inducible gene expression, and finally, organ dysfunction, are unknown. Growing evidence suggests that not only low oxygen supply to the tissues secondary to macrovascular and microvascular alterations, but also altered cellular oxygen utilization is involved in the development of multiorgan dysfunction [1]–[3]. Microbial products and innate and adaptive dysregulated immune response to infection directly affect parenchymal cells of organs and may contribute to multiorgan dysfunction.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Intensivmedizin
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Regueira, Tomas Emilio; Jakob, Stephan and Djafarzadeh, Siamak

Subjects:

600 Technology > 610 Medicine & health

ISBN:

978-3-540-77290-3

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:04

Last Modified:

08 Jun 2016 10:46

Publisher DOI:

10.1007/978-3-540-77290-3_36

URI:

https://boris.unibe.ch/id/eprint/27848 (FactScience: 112665)

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