Autophagy in cancer and chemotherapy

Yousefi, Shida; Simon, Hans-Uwe (2009). Autophagy in cancer and chemotherapy. Results and problems in cell differentiation, 49, pp. 183-190. Berlin: Springer

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Cancer cells often exhibit mutations in critical molecules of the apoptotic machinery, resulting in resistance to common anticancer therapies. In the absence of apoptosis, autophagic cell death can be an alternative form of cell death by excessive self-digestion. Therefore, autophagic cell death can be considered as a backup cell death mechanism when apoptotic cell death mechanisms fail. However, many tumors also exhibit deficiencies in autophagy that may result in both genomic instability and further anticancer drug resistance. This chapter summarizes our current understanding regarding the regulation of autophagy in tumors and discusses potential new anticancer drug treatment strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Yousefi, Shida and Simon, Hans-Uwe

ISSN:

0080-1844

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:10

Last Modified:

08 Jun 2016 10:50

PubMed ID:

19142622

URI:

https://boris.unibe.ch/id/eprint/30717 (FactScience: 194995)

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