Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients

Reubi, Jean-Claude; Waser, Beatrice; Cescato, Renzo; Gloor, Beat; Stettler, Christoph; Christ, Emanuel (2010). Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients. Journal of clinical endocrinology and metabolism, 95(5), pp. 2343-50. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2009-2487

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Somatostatin receptor subtype 2 (sst(2)) is widely expressed in neuroendocrine tumors and can be visualized immunohistochemically at the cell membrane for diagnostic purposes. Recently, it has been demonstrated in animal sst(2) tumor models in vivo that somatostatin analog treatment was able to induce a complete internalization of the tumor sst(2).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Reubi-Kattenbusch, Jean-Claude; Waser, Beatrice; Cescato, Renzo; Gloor, Beat; Stettler, Christoph and Christ, Emanuel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0021-972X

Publisher:

Endocrine Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

14 Oct 2019 16:52

Publisher DOI:

10.1210/jc.2009-2487

PubMed ID:

20228164

Web of Science ID:

000277356700045

URI:

https://boris.unibe.ch/id/eprint/355 (FactScience: 197699)

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