Donowitz, Mark; Ming Tse, C.; Fuster, Daniel Guido (2013). SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers. Molecular aspects of medicine, 34(2-3), pp. 236-251. Elsevier 10.1016/j.mam.2012.05.001
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This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Fuster, Daniel Guido |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0098-2997 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Daniel Fuster |
Date Deposited: |
31 Mar 2014 10:56 |
Last Modified: |
05 Dec 2022 14:28 |
Publisher DOI: |
10.1016/j.mam.2012.05.001 |
PubMed ID: |
23506868 |
BORIS DOI: |
10.7892/boris.41104 |
URI: |
https://boris.unibe.ch/id/eprint/41104 |
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