SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

Donowitz, Mark; Ming Tse, C.; Fuster, Daniel Guido (2013). SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers. Molecular aspects of medicine, 34(2-3), pp. 236-251. Elsevier 10.1016/j.mam.2012.05.001

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This brief review of the human Na/H exchanger gene family introduces a new classification with three subgroups to the SLC9 gene family. Progress in the structure and function of this gene family is reviewed with structure based on homology to the bacterial Na/H exchanger NhaA. Human diseases which result from genetic abnormalities of the SLC9 family are discussed although the exact role of these transporters in causing any disease is not established, other than poorly functioning NHE3 in congenital Na diarrhea.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Fuster, Daniel Guido

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0098-2997

Publisher:

Elsevier

Language:

English

Submitter:

Daniel Fuster

Date Deposited:

31 Mar 2014 10:56

Last Modified:

19 Jan 2016 11:01

Publisher DOI:

10.1016/j.mam.2012.05.001

PubMed ID:

23506868

BORIS DOI:

10.7892/boris.41104

URI:

https://boris.unibe.ch/id/eprint/41104

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