The ABCs of membrane transporters in health and disease (SLC series): introduction

Hediger, Matthias A.; Clémençon, Benjamin; Burrier, Robert E.; Bruford, Elspeth A. (2013). The ABCs of membrane transporters in health and disease (SLC series): introduction. Molecular aspects of medicine, 34(2-3), pp. 95-107. Elsevier 10.1016/j.mam.2012.12.009

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The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and "non-SLC" transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Hediger, Matthias, Clemençon, Benjamin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0098-2997

Publisher:

Elsevier

Language:

English

Submitter:

Patrizia Catucci

Date Deposited:

01 May 2014 12:39

Last Modified:

05 Dec 2022 14:29

Publisher DOI:

10.1016/j.mam.2012.12.009

PubMed ID:

23506860

URI:

https://boris.unibe.ch/id/eprint/43312

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