Hediger, Matthias

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2024

Pujol-Giménez, Jonai; Baumann, Sven P.; Ho, Manh Tin; Augustynek, Bartlomiej; Hediger, Matthias A. (2024). Functional Characterization of the Lysosomal Peptide/Histidine Transporter PHT1 (SLC15A4) by Solid Supported Membrane Electrophysiology (SSME). Biomolecules, 14(7) MDPI 10.3390/biom14070771

Radvanyi, Zsuzsa; Yoo, Eun Jin; Kandasamy, Palanivel; Salas-Bastos, Adrian; Monnerat, Sophie; Refardt, Julie; Christ-Crain, Mirjam; Hayashi, Himeka; Kondo, Yasuhiko; Jantsch, Jonathan; Rubio-Aliaga, Isabel; Sommer, Lukas; Wagner, Carsten A; Hediger, Matthias A; Kwon, Hyug Moo; Loffing, Johannes; Pathare, Ganesh (2024). Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. The journal of biological chemistry, 300(1), p. 105480. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2023.105480

Tscherrig, Dominic; Bhardwaj, Rajesh; Biner, Daniel; Dernič, Jan; Ross-Kaschitza, Daniela; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin (2024). Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. Cell calcium, 117, p. 102834. Elsevier 10.1016/j.ceca.2023.102834

2023

Nydegger, Damian T.; Pujol-Giménez, Jonai; Kandasamy, Palanivel; Vogt, Bruno; Hediger, Matthias A. (2023). Applications of the Microscale Thermophoresis Binding Assay in COVID-19 Research. Viruses, 15(7), p. 1432. MDPI 10.3390/v15071432

Pujol-Giménez, Jonai; Mirzaa, Ghayda; Blue, Elizabeth E; Albano, Giuseppe; Miller, Danny E; Allworth, Aimee; Bennett, James T; Byers, Peter H; Chanprasert, Sirisak; Chen, Jingheng; Doherty, Daniel; Folta, Andrew B; Gillentine, Madelyn A; Glass, Ian; Hing, Anne; Horike-Pyne, Martha; Leppig, Kathleen A; Parhin, Azma; Ranchalis, Jane; Raskind, Wendy H; ... (2023). Dominant-negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome. Annals of Clinical and Translational Neurology, 10(6), pp. 1046-1053. Wiley 10.1002/acn3.51786

Schlosser, Pascal; Scherer, Nora; Grundner-Culemann, Franziska; Monteiro-Martins, Sara; Haug, Stefan; Steinbrenner, Inga; Uluvar, Burulça; Wuttke, Matthias; Cheng, Yurong; Ekici, Arif B; Gyimesi, Gergely; Karoly, Edward D; Kotsis, Fruzsina; Mielke, Johanna; Gomez, Maria F; Yu, Bing; Grams, Morgan E; Coresh, Josef; Boerwinkle, Eric; Köttgen, Michael; ... (2023). Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine. Nature genetics, 55(6), pp. 995-1008. Nature America 10.1038/s41588-023-01409-8

Gyimesi, Gergely; Hediger, Matthias A (2023). Transporter-Mediated Drug Delivery. Molecules, 28(3) MDPI 10.3390/molecules28031151

2022

Sanchez-Collado, Jose; Nieto-Felipe, Joel; Jardin, Isaac; Bhardwaj, Rajesh; Berna-Erro, Alejandro; Salido, Gines M; Smani, Tarik; Hediger, Matthias A; Lopez, Jose J; Rosado, Juan A (2022). Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation. Cancers, 15(1) MDPI AG 10.3390/cancers15010203

Zaugg, Jonas; Pujol Giménez, Jonai; Cabra, Romina Silvia; Hofstetter, Wilhelm; Hediger, Matthias; Albrecht, Christiane (2022). New Insights into the Physiology of Iron Transport: An Interdisciplinary Approach. CHIMIA, 76(12), pp. 996-1004. 10.2533/chimia.2022.996

Gyimesi, Gergely; Hediger, Matthias A (3 November 2022). Transporter-Mediated Drug Delivery (Preprints). MDPI 10.20944/preprints202211.0062.v1

Lee, Sohyon; Weiss, Tobias; Bühler, Marcel; Mena, Julien; Lottenbach, Zuzanna; Wegmann, Rebekka; Bihl, Michel; Augustynek, Bartlomiej; Baumann, Sven; Goetze, Sandra; van Drogen, Audrey; Vasella, Flavio; Rushing, Elisabeth J; Wollscheid, Bernd; Hediger, Matthias A; Snijder, Berend (7 October 2022). Targeting tumour-intrinsic neural vulnerabilities of glioblastoma (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.10.07.511321

Augustynek, Bartlomiej; Gyimesi, Gergely; Dernič, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G; Peinelt, Christine; Hediger, Matthias A; Bhardwaj, Rajesh (2022). Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. Cell calcium, 105, p. 102616. Elsevier 10.1016/j.ceca.2022.102616

Verouti, Sophia N; Pujol-Giménez, Jonai; Bermudez-Lekerika, Paola; Scherler, Laeticia; Bhardwaj, Rajesh; Thomas, Aurélien; Lenglet, Sébastien; Siegrist, Mark; Hofstetter, Willy; Fuster, Daniel G; Hediger, Matthias A; Escher, Geneviève; Vogt, Bruno (2022). The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance. Frontiers in physiology, 13, p. 912277. Frontiers Research Foundation 10.3389/fphys.2022.912277

Anderegg, Manuel A; Gyimesi, Gergely; Ho, Manh Tin; Hediger, Matthias A; Fuster, Daniel G (2022). The Less Well-Known Little Brothers: The SLC9B/NHA Sodium Proton Exchanger Subfamily—Structure, Function, Regulation and Potential Drug-Target Approaches. Frontiers in physiology, 13, p. 898508. Frontiers Research Foundation 10.3389/fphys.2022.898508

Gyimesi, Gergely; Hediger, Matthias A (2022). Systematic in silico discovery of novel solute carrier-like proteins from proteomes. PLoS ONE, 17(7), e0271062. Public Library of Science 10.1371/journal.pone.0271062

2021

Pujol-Giménez, Jonai; Poirier, Marion; Bühlmann, Sven; Schuppisser, Céline; Bhardwaj, Rajesh; Awale, Mahendra; Visini, Ricardo; Javor, Sacha; Hediger, Matthias; Reymond, Jean-Louis (2021). Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library. ChemMedChem, 16(21), pp. 3306-3314. Wiley-VCH 10.1002/cmdc.202100467

Kandasamy, Palanivel; Zlobec, Inti; Nydegger, Damian T.; Pujol-Gimenez, Jonai; Bhardwaj, Rajesh; Shirasawa, Senji; Tsunoda, Toshiyuki; Hediger, Matthias A. (2021). Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. Molecular oncology, 15(10), pp. 2782-2800. Wiley 10.1002/1878-0261.12999

Havukainen, Sami; Pujol-Giménez, Jonai; Valkonen, Mari; Hediger, Matthias; Landowski, Christopher P (2021). Functional characterization of a highly specific L-arabinose transporter from Trichoderma reesei. Microbial cell factories, 20(1), p. 177. BioMed Central 10.1186/s12934-021-01666-4

Havukainen, Sami; Pujol-Gimenez, Jonai; Valkonen, Mari; Westerholm-Parvinen, Ann; Hediger, Matthias A; Landowski, Christopher P (2021). Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei. Scientific reports, 11(1), p. 14678. Springer Nature 10.1038/s41598-021-93552-7

Kar, Pulak; Lin, Yu-Ping; Bhardwaj, Rajesh; Tucker, Charles J; Bird, Gary S; Hediger, Matthias A.; Monico, Carina; Amin, Nader; Parekh, Anant B (2021). The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 118(19) National Academy of Sciences NAS 10.1073/pnas.2012908118

Anderegg, Manuel A.; Albano, Giuseppe; Hanke, Daniela; Deisl, Christine; Uehlinger, Dominik E.; Brandt, Simone; Bhardwaj, Rajesh; Hediger, Matthias A.; Fuster, Daniel G. (2021). The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney. Kidney international, 99(2), pp. 350-363. Elsevier 10.1016/j.kint.2020.08.023

Gyimesi, Gergely; Hediger, Matthias A. (2021). Systematic in silico discovery of novel solute carrier-like proteins from proteomes (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.11.19.469292

Augustynek, Bartlomiej; Gyimesi, Gergely; Dernic, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J.; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G.; Peinelt, Christine; Hediger, Matthias A.; Bhardwaj, Rajesh (2021). Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state (In Press) (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.10.26.465861

2020

Gyimesi, Gergely; Hediger, Matthias (2020). Sequence Features of Mitochondrial Transporter Protein Families. Biomolecules, 10(12) MDPI 10.3390/biom10121611

Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508

Gibhardt, Christine Silvia; Cappello, Sabrina; Bhardwaj, Rajesh; Schober, Romana; Kirsch, Sonja Agnes; Bonilla Del Rio, Zuriñe; Gahbauer, Stefan; Bochicchio, Anna; Sumanska, Magdalena; Ickes, Christian; Stejerean-Todoran, Ioana; Mitkovski, Miso; Alansary, Dalia; Zhang, Xin; Revazian, Aram; Fahrner, Marc; Lunz, Victoria; Frischauf, Irene; Luo, Ting; Ezerina, Daria; ... (2020). Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. Cell reports, 33(3), p. 108292. Cell Press 10.1016/j.celrep.2020.108292

Gyimesi, Gergely; Pujol-Gimenez, Jonai; Kanai, Yoshikatsu; Hediger, Matthias A. (2020). Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application. Pflügers Archiv : European journal of physiology, 472(9), pp. 1177-1206. Springer 10.1007/s00424-020-02433-x

Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Dernič, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A.; Lochner, Martin (2020). Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. International journal of molecular sciences, 21(16) MDPI 10.3390/ijms21165604

Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G

Poirier, Marion; Pujol-Giménez, Jonai; Manatschal, Cristina; Bühlmann, Sven; Embaby, Ahmed; Javor, Sacha; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation. RSC Medicinal Chemistry, 11(9), pp. 1023-1031. Royal Society of Chemistry 10.1039/D0MD00085J

Gyimesi, Gergely; Albano, Giuseppe; Fuster, Daniel G.; Hediger, Matthias A.; Pujol-Giménez, Jonai (2020). Correction: Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2). Journal of biological chemistry, 295(13), p. 4369. American Society for Biochemistry and Molecular Biology 10.1074/jbc.AAC120.013245

Bhardwaj, Rajesh; Augustynek, Bartlomiej S.; Ercan-Herbst, Ebru; Kandasamy, Palanivel; Seedorf, Matthias; Peinelt, Christine; Hediger, Matthias A. (2020). Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(2), pp. 252-270. 10.33594/000000218

2019

Manatschal, Cristina; Pujol-Giménez, Jonai; Poirier, Marion; Reymond, Jean-Louis; Hediger, Matthias A.; Dutzler, Raimund (2019). Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds. eLife, 8 eLife Sciences Publications 10.7554/eLife.51913

R. Cunha, Micael; Bhardwaj, Rajesh; Lindinger, Sonja; Butorac, Carmen; Romanin, Christoph; Hediger, Matthias; Reymond, Jean-Louis (2019). Photoswitchable Inhibitor of the Calcium Channel TRPV6. ACS medicinal chemistry letters, 10(9), pp. 1341-1345. American Chemical Society 10.1021/acsmedchemlett.9b00298

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (6 September 2019). Diverse effects of halogenated 2-aminoethoxydiphenyl borate derivatives on store-operated calcium entry in breast cancer cells. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Dernic, Jan; Hediger, Matthias; Lochner, Martin (6 September 2019). Synthesis of functionalized probes based on GSK7975A to study SOCE. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Pereira, Gustavo José Vasco; Tavares, Maurício Temotheo; Azevedo, Ricardo Alexandre; Martins, Barbara Behr; Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Cury, Yara; Zambelli, Vanessa Olzon; Barbosa, Euzébio Guimarães; Hediger, Matthias A.; Parise-Filho, Roberto (2019). Capsaicin-like analogue induced selective apoptosis in A2058 melanoma cells: Design, synthesis and molecular modeling. Bioorganic & medicinal chemistry, 27(13), pp. 2893-2904. Elsevier 10.1016/j.bmc.2019.05.020

Butorac, Carmen; Muik, Martin; Derler, Isabella; Stadlbauer, Michael; Lunz, Victoria; Krizova, Adéla; Lindinger, Sonja; Schober, Romana; Frischauf, Irene; Bhardwaj, Rajesh; Hediger, Matthias A.; Groschner, Klaus; Romanin, Christoph (2019). A novel STIM1-Orai1 gating interface essential for CRAC channel activation. Cell calcium, 79, pp. 57-67. Elsevier 10.1016/j.ceca.2019.02.009

Stergachis, Andrew B; Pujol Gimenez, Jonai; Gyimesi, Gergely; Fuster, Daniel Guido; Albano, Giuseppe; Troxler, Marina; Picker, Jonathan; Rosenberg, Paul A; Bergin, Ann; Peters, Jurriaan; Moufawad El Achkar, Christelle; Harini, Chellamani; Manzi, Shannon; Rotenberg, Alexander; Hediger, Matthias A.; Rodan, Lance H (2019). Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Annals of neurology, 85(6), pp. 921-926. Wiley-Blackwell 10.1002/ana.25477

Gyimesi, Gergely; Albano, Giuseppe; Fuster, Daniel Guido; Hediger, Matthias A; Pujol Gimenez, Jonai (2019). Unraveling the structural elements of pH sensitivity and substrate binding in the human zinc transporter SLC39A2 (ZIP2). Journal of biological chemistry, 294(20), pp. 8046-8063. American Society for Biochemistry and Molecular Biology 10.1074/jbc.RA118.006113

Bulla, M.; Gyimesi, Gergely; Kim, JH.; Bhardwaj, Rajesh; Hediger, Matthias; Frieden, M.; Demaurex, N. (2019). ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain. Journal of physiology, 597(2), pp. 561-582. Wiley-Blackwell 10.1113/JP277079

Lüscher, Benjamin; Surbek, Daniel; Clemençon, Benjamin; Huang, Xiao; Albrecht, Christiane; Marini, Camilla; Hediger, Matthias; Baumann, Marc (2019). Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia. Cellular physiology and biochemistry, 53(3), pp. 508-517. Cell Physiol Biochem Press 10.33594/000000154

2018

Kandasamy, Palanivel; Gyimesi, Gergely; Kanai, Yoshikatsu; Hediger, Matthias (2018). Amino acid transporters revisited: New views in health and disease. Trends in biochemical sciences, 43(10), pp. 752-789. Elsevier Current Trends 10.1016/j.tibs.2018.05.003

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Study of 2-Aminoethoxy Borate (2-APB) Analogues in MDA-MB-231 and MCF-7 Cells towards Orai Isoform-specific Modulation of Store-operated Calcium Entry (SOCE). CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Synthesis of Functionalised Probes Based on GSK7975A to Study SOCE. CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Franz, Marie-Christine; Pujol Gimenez, Jonai; Montalbetti, Nicolas; Fernandez Tenorio, Miguel; DeGrado, Timothy R.; Niggli, Ernst; Romero, Michael F.; Hediger, Matthias (2018). Reassessment of the transport mechanism of the human zinc transporter SLC39A2. Biochemistry, 57(26), pp. 3976-3986. American Chemical Society 10.1021/acs.biochem.8b00511

Clemençon, Benjamin; Lüscher, Benjamin; Hediger, Matthias (2018). Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system. Journal of pharmacological and toxicological methods, 92, pp. 67-76. Elsevier 10.1016/j.vascn.2018.03.004

2017

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Diaryl Boronic Acid Modulate Store-operated Calcium Entry (SOCE). CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Synthesis of Novel Probes based on GSK7975A to study SOCE. CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Dalghi Gens, Marianela Gisela; Ferreira-Gomes, Mariela; Montalbetti, Nicolas; Simonin, Alexandre; Strehler, Emanuel E; Hediger, Matthias; Rossi, Juan Pablo (2017). Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity. Biochimica et biophysica acta - molecular cell research, 1864(8), pp. 1413-1424. Elsevier 10.1016/j.bbamcr.2017.05.014

Pujol Gimenez, Jonai; Hediger, Matthias; Gyimesi, Gergely (2017). A novel proton transfer mechanism in the SLC11 family of divalent metal ion transporters. Scientific Reports, 7(1), p. 6194. Nature Publishing Group 10.1038/s41598-017-06446-y

Lüscher, Benjamin; Marini, Camilla; Jörger Messerli, Marianne; Huang, Xiao; Hediger, Matthias; Albrecht, Christiane; Baumann, Marc Ulrich; Surbek, Daniel (2017). Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia. Placenta, 55, pp. 94-99. Elsevier 10.1016/j.placenta.2017.04.023

Peng, J-B; Suzuki, Y; Gyimesi, Gergely; Hediger, Matthias (2017). TRPV5 and TRPV6 calcium-selective channels. In: Ashot Kozak, Juliusz; Putney, James Jr. (eds.) Calcium Entry Channels in Non-Excitable Cells. Methods in Signal Transduction Series (pp. 241-274). CRC Press

2016

Clemençon, Benjamin; Fine, Michael; Hediger, Matthias (2016). Conservation of the oligomeric state of native VDAC1 in detergent micelles. Biochimie, 127, pp. 163-172. Elsevier Masson SAS 10.1016/j.biochi.2016.05.015

Schild, Achille; Tscherrig, Dominic Armin; Wenger, Nicolas; Rajesh, Rajesh; Lüscher, Benjamin; Hediger, Matthias; Lochner, Martin (August 2016). Design, synthesis and pharmacological characterization of novel store-operated calcium channel (SOCE) modulators. CHIMIA, 70(7/8), MC125. Schweizerische Chemische Gesellschaft

Rajesh, Rajesh; Hediger, Matthias; Demaurex, Nicolas (2016). Redox modulation of STIM-ORAI signaling. Cell calcium, 60(2), pp. 142-152. Elsevier 10.1016/j.ceca.2016.03.006

Leuenberger, Michele; Ritler, Andreas; Simonin, Alexandre; Hediger, Matthias; Lochner, Martin (2016). Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. ACS chemical neuroscience, 7(5), pp. 534-539. American Chemical Society 10.1021/acschemneuro.5b00311

Hediger, Matthias; Hepworth, D (eds.) (2016). Membrane Transporters: Solute Carriers, 7. Royal Society of Chemistry

2015

Simonin, Alexandre; Montalbetti, Nicolas; Gyimesi, Gergely; Pujol Gimenez, Jonai; Hediger, Matthias (2015). The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2. Journal of biological chemistry, 290(51), pp. 30464-30474. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M115.689836

Dhayat, Nasser; Simonin, Alexandre; Anderegg, Manuel; Pathare, Ganesh Tukaram; Lüscher, Benjamin; Deisl, Christine; Albano, Giuseppe; Mordasini, David; Hediger, Matthias; Surbek, Daniel; Vogt, Bruno; Sass, Jörn; Kloeckener-Gruissem, Barbara; Fuster, Daniel Guido (2015). Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. Journal of the American Society of Nephrology, 27(5), pp. 1426-1436. American Society of Nephrology 10.1681/ASN.2015040411

César-Razquin, Adrián; Snijder, Berend; Frappier-Brinton, Tristan; Isserlin, Ruth; Gyimesi, Gergely; Bai, Xiaoyun; Reithmeier, Reinhart A; Hepworth, David; Hediger, Matthias; Edwards, Aled M; Superti-Furga, Giulio (2015). A Call for Systematic Research on Solute Carriers. Cell, 162(3), pp. 478-487. Cell Press 10.1016/j.cell.2015.07.022

Damseh, Nadirah; Simonin, Alexandre; Jalas, Chaim; Picoraro, Joseph A; Shaag, Avraham; Cho, Megan T; Yaacov, Barak; Neidich, Julie; Al-Ashhab, Motee; Juusola, Jane; Bale, Sherri; Telegrafi, Aida; Retterer, Kyle; Pappas, John G; Moran, Ellen; Cappell, Joshua; Anyane Yeboa, Kwame; Abu-Libdeh, Bassam; Hediger, Matthias; Chung, Wendy K; ... (2015). Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination. Journal of medical genetics, 52(8), pp. 541-547. BMJ Publishing Group 10.1136/jmedgenet-2015-103104

Clemençon, Benjamin; Fine, Michael; Schneider, Philipp; Hediger, Matthias (2015). Rapid method to express and purify human membrane protein using the Xenopus oocyte system for functional and low-resolution structural analysis. Methods in enzymology, 556, pp. 241-265. Academic Press 10.1016/bs.mie.2014.12.011

Simonin, Céline; Awale, Mahendra; Brand, Michael; van Deursen, Ruud; Schwartz, Julian; Fine, Michael; Kovacs, Gergely; Häfliger, Pascal; Gyimesi, Gergely; Sithampari, Abilashan; Charles, Roch-Philippe; Hediger, Matthias; Reymond, Jean-Louis (2015). Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angewandte Chemie (International ed.), 54(49), pp. 14748-14752. Wiley-VCH 10.1002/anie.201507320

Montalbetti, Nicolas; Simonin, Alexandre; Simonin, Céline; Awale, Mahendra; Reymond, Jean-Louis; Hediger, Matthias (2015). Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Biochemical pharmacology, 96(3), pp. 216-224. Elsevier 10.1016/j.bcp.2015.05.002

2014

Clemençon, Benjamin; Lüscher, Benjamin; Fine, Michael; Baumann, Marc Ulrich; Surbek, Daniel; Bonny, Olivier; Hediger, Matthias (2014). Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system. PLoS ONE, 9(10), e108852. Public Library of Science 10.1371/journal.pone.0108852

Lüscher, Benjamin; Fine, Michael; Marini, Camilla; Clemençon, Benjamin; Albrecht, Christiane; Hediger, Matthias; Surbek, Daniel; Baumann, Marc Ulrich (September 2014). PLACENTAL URIC ACID TRANSPORTER GLUT9 IS MODULATED BY FREE IODINE. Placenta, 35, A97-A97. Elsevier

Marini, Camilla; Lüscher, Benjamin; Jörger Messerli, Marianne; Sager, Ruth; Huang, Xiao; Gertsch, Jürg; Hediger, Matthias; Albrecht, Christiane; Baumann, Marc Ulrich; Surbek, Daniel (September 2014). PLACENTAL GLUCOSE TRANSPORTER (GLUT)-1 REGULATION IN PREECLAMPSIA. Placenta, 35, A83-A84. Elsevier

Jain, Arjun; Schneider, Henning; Aliyev, Eldar; Soydemir, Fatimah; Baumann, Marc Ulrich; Surbek, Daniel; Hediger, Matthias; Brownbill, Paul; Albrecht, Christiane (2014). Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response. Laboratory investigation, 94(8), pp. 873-880. Nature Publishing Group 10.1038/labinvest.2014.76

Franz, Marie-Christine; Simonin, Alexandre; Graeter, Stefanie; Hediger, Matthias; Kovacs, Gergely (2014). Development of the First Fluorescence Screening Assay for the SLC39A2 Zinc Transporter. Journal of biomolecular screening, 19(6), pp. 909-916. Sage 10.1177/1087057114526781

Clemençon, Benjamin; Fine, Michael; Lüscher, Benjamin; Baumann, Marc; Surbek, Daniel; Abriel, Hugues; Hediger, Matthias (2014). Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes. Protein expression and purification, 95, pp. 169-176. Elsevier 10.1016/j.pep.2013.11.017

Huang, Xiao; Ontsouka, Edgar; Lüthi, Michael; Hediger, Matthias; Jain, Arjun; Baumann, Marc Ulrich; Surbek, Daniel; Anderle, Pascale; Albrecht, Christiane (March 2014). Screening, Identification and Preliminary Investigation of Target Transporters in Pregnancy Pathologies. Reproductive sciences, 21(3), 183A-183A. Sage

Marini, Camilla; Lüscher, Benjamin; Jörger Messerli, Marianne; Sager, Ruth; Huang, Xiao; Gertsch, Jürg; Hediger, Matthias; Albrecht, Christiane; Baumann, Marc Ulrich; Surbek, Daniel (March 2014). Placental Glucose Transporter (GLUT1) Expression in Pre-Eclampsia. Reproductive sciences, 21(3), 304A-304A. Sage

Montalbetti, Nicolas; Dalghi Gens, Marianela Gisela; Albrecht, Christiane; Hediger, Matthias (2014). Nutrient Transport in the Mammary Gland: Calcium, Trace Minerals and Water Soluble Vitamins. Journal of mammary gland biology and neoplasia, 19(1), pp. 73-90. Springer 10.1007/s10911-014-9317-9

Montalbetti, Nicolas; Simonin, Alexandre; Dalghi Gens, Marianela Gisela; Kovacs, Gergely; Hediger, Matthias (2014). Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra. Journal of biomolecular screening, 19(6), pp. 900-908. Sage 10.1177/1087057114521663

Lüscher, Benjamin; Clemençon, Benjamin; Marini, Camilla; Huang, Xiao; Sager, Ruth; Jeanneret, Céline; Reymond, Jean-Louis; Albrecht, Christiane; Hediger, Matthias; Surbek, Daniel; Baumann, Marc Ulrich (January 2014). Placental Uric Acid Transport System: Glucose Transporter 9 (SLC2A9). Reproductive sciences, 21(3), 303A-303A. Sage

2013

Boggavarapu, Rajendra; Jeckelmann, Jean-Marc; Harder, Daniel; Schneider, Philipp; Ucurum, Zöhre; Hediger, Matthias; Fotiadis, Dimitrios (2013). Expression, purification and low-resolution structure of human vitamin C transporter SVCT1 (SLC23A1). PLoS ONE, 8(10), e76427. Public Library of Science 10.1371/journal.pone.0076427

Kovacs, Gergely; Montalbetti, Nicolas; Franz, Marie-Christine; Graeter, Stefanie; Simonin, Alexandre; Hediger, Matthias A. (2013). Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell calcium, 54(4), pp. 276-286. Elsevier 10.1016/j.ceca.2013.07.003

Marini, Camilla; Lüscher, Benjamin P.; Surbek, Daniel V.; Messerli, Marianne; Sager, Ruth; Albrecht, Christiane; Hediger, Matthias A.; Baumann, Marc (2013). Placental Glucose Transporter GLUT1 Expression in Pre-eclampsia. Placenta, 34(9), A88. Elsevier 10.1016/j.placenta.2013.06.262

Lüscher, Benjamin P.; Clemençon, Benjamin; Surbeck, Daniel V.; Huang, Xiao; Marini, Camilla; Hediger, Matthias A.; Albrecht, Christiane; Baumann, Marc (2013). Placental uric acid transport system. Placenta, 34(9), A95. Elsevier 10.1016/j.placenta.2013.06.282

Hofer, Alexandre; Kovacs, Gergely; Zappatini, Anna; Leuenberger, Michele; Hediger, Matthias A.; Lochner, Martin (2013). Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorganic & medicinal chemistry, 21(11), pp. 3202-3213. Elsevier 10.1016/j.bmc.2013.03.037

Kanai, Yoshikatsu; Clemençon, Benjamin; Simonin, Alexandre; Leuenberger, Michele; Lochner, Martin; Weisstanner, Martin; Hediger, Matthias A. (2013). The SLC1 high-affinity glutamate and neutral amino acid transporter family. Molecular aspects of medicine, 34(2-3), pp. 108-120. Elsevier 10.1016/j.mam.2013.01.001

Bürzle, Marc; Suzuki, Yoshiro; Ackermann, Daniel; Miyazaki, Hiroki; Maeda, Nobuyo; Clemençon, Benjamin; Burrier, Robert; Hediger, Matthias A. (2013). The sodium-dependent ascorbic acid transporter family SLC23. Molecular aspects of medicine, 34(2-3), pp. 436-454. Amsterdam: Elsevier 10.1016/j.mam.2012.12.002

Franz, M.-C.; Anderle, P.; Bürzle, M.; Suzuki, Y; Freeman, M. R.; Hediger, M. A.; Kovacs, G. (2013). Zinc transporters in prostate cancer. Molecular aspects of medicine, 34(2-3), pp. 735-741. Elsevier 10.1016/j.mam.2012.11.007

El-Gebali, Sara; Bentz, Susanne; Hediger, Matthias A.; Anderle, Pascale (2013). Solute carriers (SLCs) in cancer. Molecular aspects of medicine, 34(2-3), pp. 719-734. Elsevier 10.1016/j.mam.2012.12.007

Smith, David E.; Clémençon, Benjamin; Hediger, Matthias A. (2013). Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications. Molecular aspects of medicine, 34(2-3), pp. 323-336. Elsevier 10.1016/j.mam.2012.11.003

Shayakul, Chairat; Clémençon, Benjamin; Hediger, Matthias A. (2013). The urea transporter family (SLC14): physiological, pathological and structural aspects. Molecular aspects of medicine, 34(2-3), pp. 313-322. Elsevier 10.1016/j.mam.2012.12.003

Bergeron, M. J.; Clémençon, B.; Hediger, M. A.; Markovich, D. (2013). SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters. Molecular aspects of medicine, 34(2-3), pp. 299-312. Elsevier 10.1016/j.mam.2012.12.001

Montalbetti, Nicolas; Simonin, Alexandre; Kovacs, Gergely; Hediger, Matthias A. (2013). Mammalian iron transporters: Families SLC11 and SLC40. Molecular aspects of medicine, 34(2-3), pp. 270-287. Elsevier 10.1016/j.mam.2013.01.002

Hediger, Matthias A.; Clémençon, Benjamin; Burrier, Robert E.; Bruford, Elspeth A. (2013). The ABCs of membrane transporters in health and disease (SLC series): introduction. Molecular aspects of medicine, 34(2-3), pp. 95-107. Elsevier 10.1016/j.mam.2012.12.009

Deisl, Christine; Simonin, Alexandre; Anderegg, Manuel; Albano, Giuseppe; Kovacs, Gergely; Ackermann, Daniel; Moch, Holger; Dolci, Wanda; Thorens, Bernard; Hediger, Matthias; Fuster, Daniel Guido (2013). Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 110(24), pp. 10004-10009. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.1220009110

Balázs, B.; Dankó, T.; Kovács, G.; Köles, L.; Hediger, M. A.; Zsembery, Á. (2013). Investigation of the inhibitory effects of the benzodiazepine derivative, 5-BDBD on P2X4 purinergic receptors by two complementary methods. Cellular physiology and biochemistry, 32(1), pp. 11-24. Karger 10.1159/000350119

2012

Bürzle, Marc; Hediger, Matthias A (2012). Functional and physiological role of vitamin C transporters. Current topics in membranes, 70, pp. 357-375. San Diego, Calif.: Academic Press 10.1016/B978-0-12-394316-3.00011-9

Kovacs, Gergely; Montalbetti, Nicolas; Simonin, Alexandre; Danko, Tamas; Balazs, Bernadett; Zsembery, Akos; Hediger, Matthias A (2012). Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). Cell calcium, 52(6), pp. 468-80. Amsterdam: Elsevier 10.1016/j.ceca.2012.08.005

Lüscher, Benjamin; Messerli, Marianne; Surbek, Daniel; Sager, Ruth; Albrecht, Christiane; Hediger, Matthias; Baumann, Marc (2012). Placental glucose transporter (Glut)-1 expression in preeclampsia. Placenta, 33(9), A90-A90. Elsevier

2011

Kovacs, Gergely; Danko, Tamas; Bergeron, Marc J; Balazs, Bernadett; Suzuki, Yoshiro; Zsembery, Akos; Hediger, Matthias A (2011). Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell calcium, 49(1), pp. 43-55. Amsterdam: Elsevier 10.1016/j.ceca.2010.11.007

Landowski, Christopher P; Bolanz, Katrin A; Suzuki, Yoshiro; Hediger, Matthias A (2011). Chemical inhibitors of the calcium entry channel TRPV6. Pharmaceutical research, 28(2), pp. 322-30. New York, N.Y.: Springer US; http://www.springer-ny.com 10.1007/s11095-010-0249-9

Bergeron, Marc J.; Boggavarapu, Rajendra; Meury, Marcel; Ucurum, Zöhre; Caron, Luc; Isenring, Paul; Hediger, Matthias A.; Fotiadis, Dimitrios (2011). Frog oocytes to unveil the structure and supramolecular organization of human transport proteins. PLoS ONE, 6(7), e21901. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0021901

Bergeron, Marc J; Bürzle, Marc; Kovacs, Gergely; Simonin, Alexandre; Hediger, Matthias A (2011). Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Journal of biological chemistry, 286(13), pp. 11242-53. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.171728

2010

Dutzler, Raimund; Ernstb, Beat; Hediger, Matthias A; Keppler, Dietrich; Mohr, Peter; Neidhart, Werner; Märki, Hans Peter (2010). Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010. CHIMIA, 64(9), pp. 662-6. Bern: Schweizerische Chemische Gesellschaft

Luethi, Erika; Nguyen, Kong T; Bürzle, Marc; Blum, Lorenz C; Suzuki, Yoshiro; Hediger, Matthias; Reymond, Jean-Louis (2010). Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). Journal of medicinal chemistry, 53(19), pp. 7236-50. Easton, Pa.: American Chemical Society 10.1021/jm100959g

Lieben, L; Benn, B S; Ajibade, D; Stockmans, I; Moermans, K; Hediger, M A; Peng, J B; Christakos, S; Bouillon, R; Carmeliet, G (2010). Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone, 47(2), pp. 301-8. New York, N.Y.: Elsevier 10.1016/j.bone.2010.04.595

2009

Bolanz, Katrin A; Kovacs, Gergely Gy; Landowski, Christopher P; Hediger, Matthias A (2009). Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Molecular cancer research, 7(12), pp. 2000-10. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-09-0188

2008

Sung, Ji-Min; Cho, Hee-Jung; Yi, Hee; Lee, Chi-Ho; Kim, Hye-Sun; Kim, Dong-Ku; Abd El-Aty, A M; Kim, Jin-Suk; Landowski, Christopher P; Hediger, Matthias A; Shin, Ho-Chul (2008). Characterization of a stem cell population in lung cancer A549 cells. Biochemical and biophysical research communications, 371(1), pp. 163-7. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2008.04.038

Bergeron, M; Simonin, A; Bürzle, M; Hediger, M (2008). Inherited epithelial transporter disorders-an overview. Journal of inherited metabolic disease, 31(2), pp. 178-187. Lancaster, UK: Springer Netherlands 10.1007/s10545-008-0861-6

Suzuki, Yoshiro; Kovacs, Christopher S; Takanaga, Hitomi; Peng, Ji-Bin; Landowski, Christopher P; Hediger, Matthias A (2008). Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. Journal of bone and mineral research, 23(8), pp. 1249-56. Hoboken, N.J.: Wiley-Blackwell 10.1359/JBMR.080314

Suzuki, Yoshiro; Pasch, Andreas; Bonny, Olivier; Mohaupt, Markus G; Hediger, Matthias A; Frey, Felix J (2008). Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Human molecular genetics, 17(11), pp. 1613-8. Oxford: Oxford University Press 10.1093/hmg/ddn048

Bolanz, Katrin A; Hediger, Matthias A; Landowski, Christopher P (2008). The role of TRPV6 in breast carcinogenesis. Molecular cancer therapeutics, 7(2), pp. 271-9. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1535-7163.MCT-07-0478

Mackenzie, Bryan; Illing, Anthony C; Hediger, Matthias A (2008). Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. American journal of physiology - cell physiology, 294(2), C451-9. Bethesda, Md.: American Physiological Society 10.1152/ajpcell.00439.2007

Suzuki, Yoshiro; Landowski, Christopher P; Hediger, Matthias A (2008). Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annual review of physiology, 70, pp. 257-271. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev.physiol.69.031905.161003

Benn, Bryan S; Ajibade, Dare; Porta, Angela; Dhawan, Puneet; Hediger, Matthias; Peng, Ji-Bin; Jiang, Yi; Oh, Goo Taeg; Jeung, Eui-Bae; Lieben, Liesbet; Bouillon, Roger; Carmeliet, Geert; Christakos, Sylvia (2008). Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology, 149(6), pp. 3196-205. Chevy Chase, Md.: Endocrine Society 10.1210/en.2007-1655

2007

Bianco, Suzy D C; Peng, Ji-Bin; Takanaga, Hitomi; Suzuki, Yoshiro; Crescenzi, Alessandra; Kos, Claudine H; Zhuang, Liyan; Freeman, Michael R; Gouveia, Cecilia H A; Wu, Jiangping; Luo, Hongyu; Mauro, Theodora; Brown, Edward M; Hediger, Matthias A (2007). Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. Journal of bone and mineral research, 22(2), pp. 274-85. Hoboken, N.J.: Wiley-Blackwell 10.1359/JBMR.061110

Mackenzie, Bryan; Takanaga, Hitomi; Hubert, Nadia; Rolfs, Andreas; Hediger, Matthias A (2007). Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochemical journal, 403(1), pp. 59-69. London: Portland Press 10.1042/BJ20061290

2006

Konrad, Martin; Schaller, André; Seelow, Dominik; Pandey, Amit Vikram; Waldegger, Siegfried; Lesslauer, Annegret; Vitzthum, Helga; Suzuki, Yoshiro; Luk, John M; Becker, Christian; Schlingmann, Karl P; Schmid, Marcel; Rodriguez-Soriano, Juan; Ariceta, Gema; Cano, Francisco; Enriquez, Ricardo; Juppner, Harald; Bakkaloglu, Sevcan A; Hediger, Matthias A; Gallati, Sabina; ... (2006). Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. American journal of human genetics, 79(5), pp. 949-57. New York, N.Y.: Cell Press 10.1086/508617

Berger, Urs V; Hediger, Matthias A (2006). Distribution of the glutamate transporters GLT-1 (SLC1A2) and GLAST (SLC1A3) in peripheral organs. Anatomy and embryology, 211(6), pp. 595-606. Berlin: Springer-Verlag 10.1007/s00429-006-0109-x

Mackenzie, Bryan; Ujwal, M L; Chang, Min-Hwang; Romero, Michael F; Hediger, Matthias A (2006). Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes. Pflügers Archiv : European journal of physiology, 451(4), pp. 544-58. Berlin: Springer-Verlag; http://www.springer.de 10.1007/s00424-005-1494-3

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