Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome

Hashemi Gheinani, Ali; Burkhard, Fiona C.; Monastyrskaya, Katia (2013). Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome. Cellular and molecular life sciences, 70(20), pp. 3773-3789. Springer Basel 10.1007/s00018-013-1275-7

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MicroRNAs (miRNAs), a novel class of molecules regulating gene expression, have been hailed as modulators of many biological processes and disease states. Recent studies demonstrated an important role of miRNAs in the processes of inflammation and cancer, however, there are little data implicating miRNAs in peripheral pain. Bladder pain syndrome/interstitial cystitis (BPS/IC) is a clinical syndrome of pelvic pain and urinary urgency/frequency in the absence of a specific cause. BPS is a chronic inflammatory condition that might share some of the pathogenetic mechanisms with its common co-morbidities inflammatory bowel disease (IBD), asthma and autoimmune diseases. Using miRNA profiling in BPS and the information about validated miRNA targets, we delineated the signaling pathways activated in this and other inflammatory pain disorders. This review projects the miRNA profiling and functional data originating from the research in bladder cancer and immune-mediated diseases on the BPS-specific miRNAs with the aim to gain new insight into the pathogenesis of this enigmatic disorder, and highlighting the common regulatory mechanisms of pain and inflammation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Hashemi Gheinani, Ali; Burkhard, Fiona C. and Monastyrskaya-Stäuber, Katia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1420-682X

Publisher:

Springer Basel

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

23 Apr 2014 10:25

Last Modified:

01 Oct 2018 02:31

Publisher DOI:

10.1007/s00018-013-1275-7

PubMed ID:

23463234

BORIS DOI:

10.7892/boris.43727

URI:

https://boris.unibe.ch/id/eprint/43727

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