Potentials and pitfalls of clinical peptidomics and metabolomics

Leichtle, Alexander Benedikt; Dufour, Jean-François; Fiedler, Martin (2013). Potentials and pitfalls of clinical peptidomics and metabolomics. Swiss medical weekly, 143, w13801. EMH Schweizerischer Ärzteverlag 10.4414/smw.2013.13801

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Clinical peptidomics and metabolomics are two emerging "-omics" technologies with the potential not only to detect disease-specific markers, but also to give insight into the disease dependency of degradation processes and metabolic pathway alterations. However, despite their rapid evolution and major investments, a clinical breakthrough, such as the approval of a major cancer biomarker, is still out of sight. What are the reasons for this failure? In this review we focus on three important factors: sensitivity, specificity and the avoidance of bias. The way to clinical implementation of peptidomics and metabolomics is still hampered by many of the problems that had to be solved for genomics and proteomics in the past, as well as new ones that require the creation of new analytic, computational and interpretative techniques. The greatest challenge, however, will be the integration of information from different "-omics" subdisciplines into straightforward answers to clinical questions, for example, in the form of new, superior "meta-markers".

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Leichtle, Alexander Benedikt; Dufour, Jean-François and Fiedler, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-7860

Publisher:

EMH Schweizerischer Ärzteverlag

Language:

English

Submitter:

Barbara Keller

Date Deposited:

12 Jun 2014 10:12

Last Modified:

17 Mar 2016 09:27

Publisher DOI:

10.4414/smw.2013.13801

PubMed ID:

23771768

BORIS DOI:

10.7892/boris.49514

URI:

https://boris.unibe.ch/id/eprint/49514

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