Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

Affentranger, Sarah; Martinelli, Sibylla; Hahn, Jonas; Rossy, Jérémie; Niggli, Verena (2011). Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. BMC cell biology, 12, p. 28. London: BioMed Central 10.1186/1471-2121-12-28

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Different types of membrane microdomains (rafts) have been postulated to be present in the rear and front of polarized migrating T-lymphocytes. Disruption of rafts by cholesterol sequestration prevents T-cell polarization and migration. Reggie/flotillin-1 and -2 are two highly homologous proteins that are thought to shape membrane microdomains. We have previously demonstrated the enrichment of flotillins in the uropod of human neutrophils. We have now investigated mechanisms involved in chemokine-induced flotillin reorganization in human T-lymphocytes, and possible roles of flotillins in lymphocyte polarization.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Inflammatory Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Affentranger, Sarah; Martinelli, Sibylla; Rossy, Jérémie and Niggli, Verena

ISSN:

1471-2121

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

11 Dec 2014 09:45

Publisher DOI:

10.1186/1471-2121-12-28

PubMed ID:

21696602

Web of Science ID:

000292540700001

BORIS DOI:

10.7892/boris.5533

URI:

https://boris.unibe.ch/id/eprint/5533 (FactScience: 210286)

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