Affentranger, Sarah; Martinelli, Sibylla; Hahn, Jonas; Rossy, Jérémie; Niggli, Verena (2011). Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. BMC cell biology, 12, p. 28. London: BioMed Central 10.1186/1471-2121-12-28
|
Text
1471-2121-12-28.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (8MB) | Preview |
Different types of membrane microdomains (rafts) have been postulated to be present in the rear and front of polarized migrating T-lymphocytes. Disruption of rafts by cholesterol sequestration prevents T-cell polarization and migration. Reggie/flotillin-1 and -2 are two highly homologous proteins that are thought to shape membrane microdomains. We have previously demonstrated the enrichment of flotillins in the uropod of human neutrophils. We have now investigated mechanisms involved in chemokine-induced flotillin reorganization in human T-lymphocytes, and possible roles of flotillins in lymphocyte polarization.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Inflammatory Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Affentranger, Sarah, Martinelli, Sibylla, Rossy, Jérémie, Niggli, Verena |
ISSN: |
1471-2121 |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:18 |
Last Modified: |
05 Dec 2022 14:04 |
Publisher DOI: |
10.1186/1471-2121-12-28 |
PubMed ID: |
21696602 |
Web of Science ID: |
000292540700001 |
BORIS DOI: |
10.7892/boris.5533 |
URI: |
https://boris.unibe.ch/id/eprint/5533 (FactScience: 210286) |
Actions (login required)
 |
Edit item |