Malignant pheochromocytomas and paragangliomas: a diagnostic challenge

Gimm, Oliver; DeMicco, Catherine; Perren, Aurel; Giammarile, Francesco; Walz, Martin K; Brunaud, Laurent (2012). Malignant pheochromocytomas and paragangliomas: a diagnostic challenge. Langenbeck's archives of surgery, 397(2), pp. 155-77. Berlin: Springer 10.1007/s00423-011-0880-x

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Malignant pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare disorders arising from the adrenal gland, from the glomera along parasympathetic nerves or from paraganglia along the sympathetic trunk. According to the WHO classification, malignancy of PCCs and PGLs is defined by the presence of metastases at non-chromaffin sites distant from that of the primary tumor and not by local invasion. The overall prognosis of metastasized PCCs/PGLs is poor. Surgery offers currently the only change of cure. Preferably, the discrimination between malignant and benign PCCs/PGLs should be made preoperatively.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Perren, Aurel

ISSN:

1435-2443

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

17 Mar 2015 19:23

Publisher DOI:

10.1007/s00423-011-0880-x

PubMed ID:

22124609

Web of Science ID:

000300493600003

URI:

https://boris.unibe.ch/id/eprint/5535 (FactScience: 210288)

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