Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides

Laverman, Peter; Joosten, Lieke; Eek, Annemarie; Roosenburg, Susan; Peitl, Petra Kolenc; Maina, Theodosia; Mäcke, Helmut; Aloj, Luigi; von Guggenberg, Elisabeth; Sosabowski, Jane K; de Jong, Marion; Reubi, Jean-Claude; Oyen, Wim J G; Boerman, Otto C (2011). Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides. European journal of nuclear medicine and molecular imaging, 38(8), pp. 1410-6. Berlin: Springer 10.1007/s00259-011-1806-0

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Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours such as medullary thyroid carcinomas and small-cell lung cancers. Due to this high expression, CCK-2 receptors might be suitable targets for radionuclide imaging and/or radionuclide therapy. Several CCK-2 receptor-binding radiopeptides have been developed and some have been tested in patients. Here we aimed to compare the in vivo tumour targeting properties of 12 (111)In-labelled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated gastrin/CCK2 receptor-binding peptides.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1619-7070

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:18

Last Modified:

14 Oct 2019 16:34

Publisher DOI:

10.1007/s00259-011-1806-0

PubMed ID:

21461732

Web of Science ID:

000292272700002

URI:

https://boris.unibe.ch/id/eprint/5561 (FactScience: 210315)

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