Economou, Mary; Schöni, Liliane; Hammer, Caroline; Galván Hernández, José Alberto; Müller, Dominique-Elisabeth; Zlobec, Inti (2014). Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains. Clinical and translation research, 3(1), p. 4. Springer 10.1186/2001-1326-3-4
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The use of paraffin slides and tissue microarrays (TMA) is indispensable for translational research. However, storage of paraffin slides over time has a substantial detrimental effect on the quality and reliability of immunohistochemistry stains. Particularly affected by this issue may be any collaborative efforts where paraffin slides or TMAs are shipped to central laboratories and then 'biobanked' for some time until use. This article summarizes some of the key issues affecting loss of antigenicity on paraffin slides and some simple storage solutions to help maintain high quality immunohistochemistry results when paraffin slides must be stored for a certain time prior to use.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Service Sector > Institute of Pathology > Translational Research Unit |
UniBE Contributor: |
Economou, Mary, Schöni, Liliane, Hammer, Caroline, Galván Hernández, José Alberto, Müller, Dominique-Elisabeth, Zlobec, Inti |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2001-1326 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Doris Haefelin |
Date Deposited: |
13 Feb 2015 11:28 |
Last Modified: |
05 Dec 2022 14:40 |
Publisher DOI: |
10.1186/2001-1326-3-4 |
PubMed ID: |
24636624 |
BORIS DOI: |
10.7892/boris.63206 |
URI: |
https://boris.unibe.ch/id/eprint/63206 |
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