Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains.

Economou, Mary; Schöni, Liliane; Hammer, Caroline; Galván Hernández, José Alberto; Müller, Dominique-Elisabeth; Zlobec, Inti (2014). Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains. Clinical and translation research, 3(1), p. 4. Springer 10.1186/2001-1326-3-4

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The use of paraffin slides and tissue microarrays (TMA) is indispensable for translational research. However, storage of paraffin slides over time has a substantial detrimental effect on the quality and reliability of immunohistochemistry stains. Particularly affected by this issue may be any collaborative efforts where paraffin slides or TMAs are shipped to central laboratories and then 'biobanked' for some time until use. This article summarizes some of the key issues affecting loss of antigenicity on paraffin slides and some simple storage solutions to help maintain high quality immunohistochemistry results when paraffin slides must be stored for a certain time prior to use.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Economou, Mary; Schöni, Liliane; Hammer, Caroline; Galván Hernández, José Alberto; Müller, Dominique-Elisabeth and Zlobec, Inti

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2001-1326

Publisher:

Springer

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

13 Feb 2015 11:28

Last Modified:

26 Jun 2016 01:58

Publisher DOI:

10.1186/2001-1326-3-4

PubMed ID:

24636624

BORIS DOI:

10.7892/boris.63206

URI:

https://boris.unibe.ch/id/eprint/63206

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