Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

Galon, Jérôme; Mlecnik, Bernhard; Bindea, Gabriela; Angell, Helen K; Berger, Anne; Lagorce, Christine; Lugli, Alessandro; Zlobec, Inti; Hartmann, Arndt; Bifulco, Carlo; Nagtegaal, Iris D; Palmqvist, Richard; Masucci, Giuseppe V; Botti, Gerardo; Tatangelo, Fabiana; Delrio, Paolo; Maio, Michele; Laghi, Luigi; Grizzi, Fabio; Asslaber, Martin; ... (2014). Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. Journal of pathology, 232(2), pp. 199-209. Wiley 10.1002/path.4287

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The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named 'Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

Lugli, Alessandro and Zlobec, Inti

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0022-3417

Publisher:

Wiley

Language:

English

Submitter:

Doris Haefelin

Date Deposited:

13 Feb 2015 09:17

Last Modified:

27 Feb 2015 14:14

Publisher DOI:

10.1002/path.4287

PubMed ID:

24122236

Uncontrolled Keywords:

Immunoscore, T cells, classification, colon carcinoma, colorectal cancer, immune response, predictive markers, prognostic markers, tumour microenvironment

BORIS DOI:

10.7892/boris.63213

URI:

https://boris.unibe.ch/id/eprint/63213

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