Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina

Steiner, Patrick; Enzmann, Volker; Wolf, Sebastian; Bossen, Anke; Meier, Christoph; Sznitman, Raphael (February 2015). Assessment of ultra-high resolution optical coherence tomography for monitoring tissue effects caused by laser photocoagulation of ex-vivo porcine retina. In: Photonics West, Optical Interactions with Tissue and Cells XXVI. Proc. SPIE: Vol. 9321 (p. 932112). SPIE 10.1117/12.2079351

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Retinal laser photocoagulation is an established and successful treatment for a variety of retinal diseases. While being a valuable treatment modality, laser photocoagulation shows the drawback of employing high energy lasers which are capable of physically destroying the neural retina. For reliable therapy, it is therefore crucial to closely monitor the therapy effects caused in the retinal tissue. A depth resolved representation of optical tissue properties as provided by optical coherence tomography may provide valuable information about the treatment effects in the retinal layers if recorded simultaneously to laser coagulation. Therefore, in this work, the use of ultra-high resolution optical coherence tomography to represent tissue changes caused by conventional and selective retinal photocoagulation is investigated. Laser lesions were placed on porcine retina ex-vivo using a 577 nm laser as well as a pulsed laser at 527 nm built for selective treatment of the retinal pigment epithelium. Applied energies were varied to generate lesions best representing the span from under- to overtreatment. The lesions were examined using a custom-designed optical coherence tomography system with an axial resolution of 1.78 μm and 70 kHz Ascan rate. Optical coherence tomography scans included volume scans before and after irradiation, as well as time lapse scans (Mscan) of the lesions. Results show OCT lesion visibility thresholds to be below the thresholds of ophthalmoscopic inspection. With the ultra-high resolution OCT, 42% - 44% of ophthalmoscopically invisible lesions could be detected and lesions that were under- or overexposed could be distinguished using the OCT data.

Item Type:

Conference or Workshop Item (Paper)

Division/Institute:

10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy > ARTORG Center - Ophthalmic Technology Lab
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Steiner, Patrick; Enzmann, Volker; Wolf, Sebastian and Sznitman, Raphael

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

Series:

Proc. SPIE

Publisher:

SPIE

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Patrick Steiner

Date Deposited:

10 Apr 2015 16:00

Last Modified:

26 Jun 2016 02:00

Publisher DOI:

10.1117/12.2079351

URI:

https://boris.unibe.ch/id/eprint/66309

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