NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions

Schlapbach, C; Zawodniak, A; Irla, N; Adam, J; Hunger, R E; Yerly, D; Pichler, W J; Yawalkar, N (2011). NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions. Allergy, 66(11), pp. 1469-76. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02677.x

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The spectrum of cutaneous adverse drug reactions (cADRs) ranges from benign presentations to severe life-threatening forms such as toxic epidermal necrolysis (TEN). In TEN, granulysin has been shown to be the key cytotoxic molecule. Still, little is known about the expression of granulysin in other cADRs. As an important source of granulysin, natural killer (NK) cells are of major interest in cADRs. Recently, NKp46 has been identified as the most selective NK-cell marker. However, the role of NKp46(+) cells in cADRs and their contribution to granulysin expression remain to be elucidated.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Schlapbach, Christoph; Irla, Nathalie; Hunger, Robert; Pichler, Werner Joseph and Yawalkar, Nikhil

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:21

Last Modified:

06 Dec 2013 13:27

Publisher DOI:

10.1111/j.1398-9995.2011.02677.x

PubMed ID:

21819408

Web of Science ID:

000296046100011

URI:

https://boris.unibe.ch/id/eprint/7069 (FactScience: 212219)

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