Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors

Fani, Melpomeni; Mueller, Andreas; Tamma, Maria-Luisa; Nicolas, Guillaume; Rink, Hans R; Cescato, Renzo; Reubi, Jean Claude; Maecke, Helmut R (2010). Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors. Journal of nuclear medicine, 51(11), pp. 1771-9. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.110.076695

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A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)-positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet. Hypothesizing that the introduction of conformational constraints may lead to receptor subtype selectivity or may help to delineate structural features determining pansomatostatin potency, we developed and evaluated first examples of this new class of potential radiotracers for imaging or therapy of neuroendocrine tumors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Cescato, Renzo and Reubi, Jean-Claude

ISSN:

0161-5505

Publisher:

Society of Nuclear Medicine

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.2967/jnumed.110.076695

PubMed ID:

20956465

Web of Science ID:

000283766000045

URI:

https://boris.unibe.ch/id/eprint/707 (FactScience: 200441)

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