Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog

Reubi, Jean Claude; Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E (2010). Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog. European journal of nuclear medicine and molecular imaging, 37(8), pp. 1551-8. Berlin: Springer-Verlag 10.1007/s00259-010-1445-x

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Peptide receptor targeting has become an increasingly attractive method to target tumors diagnostically and radiotherapeutically. Peptides linked to a variety of chelators have been developed for this purpose. They have, however, rarely been tested for their agonistic or antagonistic properties. We report here on a somatostatin antagonist that switched to an agonist upon coupling to a DOTA chelator.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Reubi, Jean-Claude; Cescato, Renzo and Waser, Beatrice

ISSN:

1619-7070

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:08

Last Modified:

26 Jun 2018 14:25

Publisher DOI:

10.1007/s00259-010-1445-x

PubMed ID:

20396884

Web of Science ID:

000280639400014

BORIS DOI:

10.7892/boris.710

URI:

https://boris.unibe.ch/id/eprint/710 (FactScience: 200444)

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