Basophils exhibit antibacterial activity through extracellular trap formation.

Yousefi, Shida; Morshed, Md. Mahbubul; Amini, Poorya; Stojkov, Darko; Simon, Dagmar; von Gunten, Stephan; Kaufmann, Thomas; Simon, Hans-Uwe (2015). Basophils exhibit antibacterial activity through extracellular trap formation. Allergy, 70(9), pp. 1184-1188. Wiley-Blackwell 10.1111/all.12662

[img] Text
Basophils exhibit antibacterial activity through extracellular trap formation.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (645kB) | Request a copy

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Yousefi, Shida; Morshed, Md. Mahbubul; Amini, Poorya; Stojkov, Darko; Simon, Dagmar; von Gunten, Stephan; Kaufmann, Thomas and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Debora Scherrer

Date Deposited:

11 Sep 2015 08:00

Last Modified:

26 May 2016 10:13

Publisher DOI:

10.1111/all.12662

PubMed ID:

26043360

Uncontrolled Keywords:

basophil extracellular trap; basophils; extracellular bacterial killing; innate immunity; phagocytosis

BORIS DOI:

10.7892/boris.71497

URI:

https://boris.unibe.ch/id/eprint/71497

Actions (login required)

Edit item Edit item
Provide Feedback