In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa.

Pires, João; Siriwardena, Thissa N.; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Luzzaro, Francesco; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis; Endimiani, Andrea (2015). In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 59(12), pp. 7915-7918. American Society for Microbiology 10.1128/AAC.01853-15

[img] Text
7915.full.pdf+html - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (8kB) | Request a copy

The in vitro activity of the novel antimicrobial peptide dendrimer G3KL was evaluated against 32 Acinetobacter baumannii (including 10 OXA-23, 7 OXA-24, and 11 OXA-58 carbapenemase producers) and 35 Pseudomonas aeruginosa (including 18 VIM and 3 IMP carbapenemase producers) strains and compared to the activities of standard antibiotics. Overall, both species collections showed MIC50/90 values of 8/8 μg/ml and minimum bactericidal concentrations at which 50% or 90% of strains tested are killed (MBC50/90) of 8/8 μg/ml. G3KL is a promising molecule with antibacterial activity against multidrug-resistant and extensively drug-resistant A. baumannii and P. aeruginosa isolates.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > General Bacteriology
08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Do Couto Pires, Joao Pedro; Siriwardena, Thissa; Stach, Michaela; Tinguely, Regula; Kasraian Fard, Sara; Leib, Stephen; Darbre, Tamis; Reymond, Jean-Louis and Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
500 Science > 540 Chemistry

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Stephen Leib

Date Deposited:

07 Jan 2016 15:15

Last Modified:

08 Feb 2017 14:07

Publisher DOI:

10.1128/AAC.01853-15

PubMed ID:

26459893

BORIS DOI:

10.7892/boris.74425

URI:

https://boris.unibe.ch/id/eprint/74425

Actions (login required)

Edit item Edit item
Provide Feedback