Comparison of Mixed and Kinematic Uniform Boundary Conditions in Homogenized Elasticity of Femoral Trabecular Bone Using Microfinite Element Analyses

Panyasantisuk, Jarunan; Gross, Thomas; Pahr, Dieter; Zysset, Philippe (2015). Comparison of Mixed and Kinematic Uniform Boundary Conditions in Homogenized Elasticity of Femoral Trabecular Bone Using Microfinite Element Analyses. Journal of biomechanical engineering, 137(1), 011002. American Society of Mechanical Engineers ASME 10.1115/1.4028968

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Mechanical properties of human trabecular bone play an important role in age-related bone fragility and implant stability. Micro-finite element (microFE) analysis allows computing the apparent elastic properties of trabecular bone biopsies, but the results depend on the type of applied boundary conditions (BCs). In this study, 167 femoral trabecular cubic biopsies with a side length of 5.3 mm were analyzed using microFE analysis to compare their stiffness systematically with kinematic uniform boundary conditions (KUBCs) and periodicity-compatible mixed uniform boundary conditions (PMUBCs). The obtained elastic constants were then used in the volume fraction and fabric-based orthotropic Zysset-Curnier model to identify their respective model parameters. As expected, PMUBCs lead to more compliant apparent elastic properties than KUBCs, especially in shear. The differences in stiffness decreased with bone volume fraction and mean intercept length. Unlike KUBCs, PMUBCs were sensitive to heterogeneity of the biopsies. The Zysset-Curnier model predicted apparent elastic constants successfully in both cases with adjusted coefficients of determination of 0.986 for KUBCs and 0.975 for PMUBCs. The role of these boundary conditions in finite element analyses of whole bones and bone-implant systems will need to be investigated in future work.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Panyasantisuk, Jarunan and Zysset, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0148-0731

Publisher:

American Society of Mechanical Engineers ASME

Funders:

[4] Swiss National Science Foundation

Projects:

[UNSPECIFIED] Inclusion of cortex and fabric in QCT-based patient-specific finite element analysis of the proximal femur

Language:

English

Submitter:

Jarunan Panyasantisuk

Date Deposited:

09 Feb 2016 11:47

Last Modified:

09 Feb 2016 11:47

Publisher DOI:

10.1115/1.4028968

PubMed ID:

25363247

URI:

https://boris.unibe.ch/id/eprint/75236

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