A Call for Systematic Research on Solute Carriers

César-Razquin, Adrián; Snijder, Berend; Frappier-Brinton, Tristan; Isserlin, Ruth; Gyimesi, Gergely; Bai, Xiaoyun; Reithmeier, Reinhart A; Hepworth, David; Hediger, Matthias; Edwards, Aled M; Superti-Furga, Giulio (2015). A Call for Systematic Research on Solute Carriers. Cell, 162(3), pp. 478-487. Cell Press 10.1016/j.cell.2015.07.022

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Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Gyimesi, Gergely and Hediger, Matthias

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0092-8674

Publisher:

Cell Press

Language:

English

Submitter:

Kevin Marc Rupp

Date Deposited:

22 Feb 2016 12:11

Last Modified:

16 Feb 2018 10:11

Publisher DOI:

10.1016/j.cell.2015.07.022

PubMed ID:

26232220

BORIS DOI:

10.7892/boris.75713

URI:

https://boris.unibe.ch/id/eprint/75713

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