Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

Eloranta, Jyrki J; Wenger, Christa; Mwinyi, Jessica; Hiller, Christian; Gubler, Christoph; Vavricka, Stephan R; Fried, Michael; Kullak-Ublick, Gerd A; Swiss IBD Cohort Study Group, The (2011). Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. Pharmacogenetics and genomics, 21(9), pp. 559-64. London: Lippincott Williams & Wilkins 10.1097/FPC.0b013e328348f70c

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Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Kullak-Ublick, Gerd


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

05 Dec 2022 14:06

Publisher DOI:


PubMed ID:


Additional Information:

Christoph Müller (Institute of Pathology) is Member of the Swiss IBD Cohort Study Group



URI: (FactScience: 213260)

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