Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

Eloranta, Jyrki J; Wenger, Christa; Mwinyi, Jessica; Hiller, Christian; Gubler, Christoph; Vavricka, Stephan R; Fried, Michael; Kullak-Ublick, Gerd A; Swiss IBD Cohort Study Group (Müller C), (2011). Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease. Pharmacogenetics and genomics, 21(9), pp. 559-64. London: Lippincott Williams & Wilkins

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Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine

UniBE Contributor:

von Känel, Roland

ISSN:

1744-6872

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:23

Last Modified:

17 Mar 2015 21:02

PubMed ID:

21832969

URI:

https://boris.unibe.ch/id/eprint/7887 (FactScience: 213260)

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